AI Article Synopsis
- A methanolic extract from the roots of Polygala tenuifolia reduced nitric oxide production in LPS-treated BV2 microglia cells, indicating potential anti-inflammatory properties.
- Five xanthones and five phenylpropanoids were isolated from the extract, using a method called bioactivity-guided fractionation.
- Specific compounds, particularly 1, 2, 4, 5, and 7, exhibited significant inhibition of NO production at concentrations between 10.0 to 100.0 μM, supporting further investigation into their therapeutic potential.
Article Abstract
A methanolic extract of the roots of Polygala tenuifolia (Polygalaceae) significantly attenuated nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Five xanthones, 1-hydroxy-7-methoxyxanthone (1), 3,6-dihydroxy-1,2,7-trimethoxyxanthone (2), 1,3,6-trihydroxy-2,7-dimethoxyxanthone (3), 1,7-dihydroxy-2,3-dimethoxyxanthone (4) and 1,7-dihydroxy-3-methoxyxanthone (5), and five phenylpropanoids, 4-hydroxy-3-methoxypropiophenone (6), methyl 4-hydroxy-3-methoxycinnamic acid (7), 3,4,5-trimethoxycinnamic acid (8), 4-methoxycinnamic acid (9) and β-d-(3-O-sinapoyl) fructofuranosyl-α-d-(6-O-sinapoyl)glucopyranoside (10), were isolated from CHCl(3) fraction using bioactivity-guided fractionation. Among these compounds, compounds 1, 2, 4, 5 and 7 showed significant inhibitory effects on LPS-induced NO production in BV2 microglia cells at the concentration ranging from 10.0 to 100.0 μM.
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| http://dx.doi.org/10.3109/14756366.2011.562203 | DOI Listing |
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