Cardiovascular complications are common in patients with anorexia nervosa, an eating disorder resulting in severe malnutrition that affects multiple organ systems. Sinus bradycardia is the most common cardiovascular physical finding and the most common arrhythmia in patients with anorexia nervosa. It is important to appreciate the significance of sinus bradycardia in this clinical setting because it may be associated with sudden death, especially in the presence of other arrhythmias or EKG abnormalities, such as prolongation of the QTc interval. Since sinus bradycardia can occur in up to 95% of patients with anorexia nervosa, its clinical correlation with more lethal arrhythmias cannot be overemphasized. Physicians must be aware of the common cardiac findings on the physical examination of a patient with anorexia nervosa in order to refer those patients to tertiary care centers for treatment by eating disorder specialists.
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J Int Neuropsychol Soc
January 2025
Department of Psychiatry, Ankara University, Ankara, Turkey.
Objectives: This study compared cognitive flexibility (CF) and emotion recognition (ER) in adolescents with eating disorders (ED) to a healthy group.
Methods: Forty healthy individuals aged 12-18 years with no psychiatric diagnosis and 46 patients diagnosed with anorexia nervosa (AN), bulimia nervosa (BN), or binge eating disorder (BED) according to DSM-5 criteria participated. CF was assessed using the Cognitive Flexibility Scale (CFS), Stroop Test, and Berg Card Sorting Test (BCST), while ER was evaluated using the test of perception of affect via nonverbal cues.
Eat Behav
January 2025
Cincinnati Children's Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:
Objective: This study identified mealtime challenges and emotions experienced during challenges among adolescents with anorexia nervosa (AN) or atypical anorexia nervosa (AAN) and their caregivers during the early phase of family-based treatment (FBT).
Method: Caregivers with high expressed emotion (i.e.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Graduate School of PLA Medical College, Chinese PLA General Hospital and PLA Medical College, 28 Fu Xing Road, Beijing, 100083, China.
Extensive researches illuminate a potential interplay between immune traits and psychiatric disorders. However, whether there is the causal relationship between the two remains an unresolved question. We conducted a two-sample bidirectional mendelian randomization by utilizing summary data of 731 immune cell traits from genome-wide association studies (GCST90001391-GCST90002121)) and 11 psychiatric disorders including attention deficit/hyperactivity disorder (ADHD), anxiety disorder, autism spectrum disorder (ASD), bipolar disorder (BIP), anorexia nervosa (AN), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), Tourette syndrome (TS), post-traumatic stress disorder (PTSD), schizophrenia (SCZ), and substance use disorders (cannabis) (SUD) from the Psychiatric Genomics Consortium (PGC).
View Article and Find Full Text PDFEur Arch Psychiatry Clin Neurosci
January 2025
Lanzhou University Second Hospital, Lanzhou, China.
Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often share multiple similar symptoms and are highly comorbid; however, the common and distinct brain neuroanatomy of these two diseases are unclear. The current study attempted to identify the overlapping and different gray matter volume (GMV) between AN and OCD. We conducted a voxel-wise meta-analysis of GMV using the latest Seed-based d Mapping with Permutation of Subject Images Toolbox (SDM-PSI) software.
View Article and Find Full Text PDFFront Psychiatry
January 2025
Department of Specialist Training, Institution for Integrated Mental Health Care (GGz) Drenthe, Assen, Netherlands.
Objective: Obsessive compulsive disorder (OCD) and anorexia nervosa (AN) are conditions associated with poor cognitive flexibility, a factor considered to interfere with treatment, but research into the relationship between cognitive flexibility and treatment outcome is limited. This study explores whether baseline measures of cognitive flexibility predict outcomes in OCD and AN, evaluates whether changes in these measures contribute to treatment outcome, and evaluates the effectiveness of adjunctive cognitive remediation therapy (CRT) in improving cognitive flexibility.
Methods: This secondary analysis utilized linear mixed model analysis on data from a randomized controlled multicenter clinical trial involving adult participants with OCD (n=71) AND AN (n=61).
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