Background: There are different abridged versions of the tinnitus questionnaire (TQ) and reference values for grading tinnitus-related distress, the diagnostic value of which is unclear, as is the relation of sensitivity to specificity, as well as positive and negative predictive values. The present study is aimed at clarifying these issues and at benchmarking the existing abridged TQ versions.
Patients And Methods: TQ data from 209 outpatients who had tinnitus for a period of at least 4 months were collected at the beginning of treatment. The rate of correct severity ratings, the quality of making a distinction between (extremely) severe and compensated/moderate tinnitus (area-under curve under the receiver-operating-characteristics curve, and rate of correct classifications), as well as positive and negative predictive values were calculated.
Results: Applying unspecific reference values (independent of inpatient/outpatient status), the most favourable evaluation was achieved by the shortest TQ version (10 items). With the 12-item version (mini-TQ), better classification was achieved when reference values specific for outpatients were applied instead of unspecific values.
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http://dx.doi.org/10.1007/s00106-011-2296-x | DOI Listing |
EJNMMI Res
January 2025
Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
Background: In clinical practice, several radiopharmaceuticals are used for PSMA-PET imaging, each with distinct biodistribution patterns. This may impact treatment decisions and outcomes, as eligibility for PSMA-directed radioligand therapy is usually assessed by comparing tumoral uptake to normal liver uptake as a reference. In this study, we aimed to compare tracer uptake intraindividually in various reference regions including liver, parotid gland and spleen as well as the respective tumor-to-background ratios (TBR) of different F-labeled PSMA ligands to today's standard radiopharmaceutical Ga-PSMA-11 in a series of patients with biochemical recurrence of prostate cancer who underwent a dual PSMA-PET examination as part of an individualized diagnostic approach.
View Article and Find Full Text PDFEnviron Monit Assess
January 2025
Department of Landscape Architecture, Remote Sensing and GIS Laboratory, University of Cukurova, Adana, 01330, Turkey.
Recent advancements in satellite technology have greatly expanded data acquisition capabilities, making satellite imagery more accessible. Despite these strides, unlocking the full potential of satellite images necessitates efficient interpretation. Image classification, a widely adopted for extracting valuable information, has seen a surge in the application of deep learning methodologies due to their effectiveness.
View Article and Find Full Text PDFToxicol Sci
January 2025
ToxStrategies LLC, Austin, Texas, USA.
Traditional approaches for quantitatively characterizing uncertainty in risk assessment require adaptation to accommodate increased reliance on observational (vs. experimental) studies in developing toxicity values. Herein, a case study with PFOA and PFOS and vaccine response explores approaches for qualitative and-where possible-quantitative assessments of uncertainty at each step in the toxicity value development process when using observational data, including review and appraisal of individual studies, candidate study selection, dose-response modeling, and application of uncertainty factors.
View Article and Find Full Text PDFJ Extracell Biol
January 2025
RoseBio Milano Italy.
Current state-of-the-art tools for analysing extracellular vesicles (EVs) offer either highly sensitive but unidimensional bulk measurements of EV components, or high-resolution multiparametric single-particle analyses which lack standardization and appropriate reference materials. This limits the accuracy of the assessment of marker abundance and overall marker distribution amongst individual EVs, and finally, the understanding of true EV heterogeneity. In this study, we aimed to define the standardized operating procedures and reference material for fluorescent characterization of EVs with two commonly used EV analytical platforms-nanoparticle tracking analysis (NTA) and nano-flow cytometry (nFCM).
View Article and Find Full Text PDFRSC Med Chem
December 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq Baghdad 10023 Iraq.
Many cancers have displayed resistance to chemotherapeutic drugs over the past few decades. EGFR has emerged as a leading target for cancer therapy inhibiting tumor angiogenesis. Besides, studies strongly suggest that blocking telomerase activity could be an effective way to control the growth of certain cancer cells.
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