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Therapeutic potentials and targeting strategies of quercetin on cancer cells: Challenges and future prospects.
Phytomedicine
October 2024
Department of Chemistry, School of Advanced Science, Vellore Institute of Technology, Vellore, 632014 Tamil Nadu, India. Electronic address:
Article Synopsis
- Quercetin, a flavonoid found in plants, has been studied for its potential anti-cancer properties and targets various cancer cell signaling pathways, leading to cell death (apoptosis).* -
- The research highlights the pros and cons of using quercetin in cancer treatment, noting its effectiveness as well as issues like hydrophobicity and gastrointestinal instability that hinder its pharmaceutical use.* -
- Future advancements may involve utilizing bio-nanomaterials to improve the delivery and efficacy of quercetin in targeting cancer cells effectively.*
Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway.
J Toxicol Sci
September 2021
Department of Pharmacy, Sanmen People's Hospital of Zhejiang, China.
Cardiovascular complications have been well documented as the downside to conventional cancer chemotherapy. As a notable side effect of cisplatin (CDDP), cardiotoxicity represents a major obstacle to the successful treatment of cancer. It has been reported that Salvianolic acid B (SalB) possesses cardioprotective quality.
View Article and Find Full Text PDFKaempferol attenuated cisplatin-induced cardiac injury via inhibiting STING/NF-κB-mediated inflammation.
Am J Transl Res
December 2020
Department of Anesthesiology, The Cancer Hospital of The University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences Hangzhou 310012, Zhejiang, China.
Cardiovascular complications have been well documented as the downside to conventional cancer chemotherapy. As a notable side effect of cisplatin, cardiotoxicity represents a major obstacle to the successful treatment of cancer. It has been reported that kaempferol (KPF) possesses cardioprotective and anti-inflammatory qualities.
View Article and Find Full Text PDFDistinct functions of AKT isoforms in breast cancer: a comprehensive review.
Cell Commun Signal
November 2019
Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Background: AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g.
View Article and Find Full Text PDFGreen synthesis of silver nanoparticles from mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats.
Artif Cells Nanomed Biotechnol
December 2019
a Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun , Jilin , China.
The rhizome of possesses immense pharmaceutical properties like antioxidant, anti-inflammatory, antiapoptotic, anticancer activities. The foremost downside of herbal-based drugs is their poor bioavailability, to trounce this we synthesized a herbal based silver nanodrug with rhizome extract and assessed its effect against the cisplatin-induced nephrotoxicity in model. The biosynthesized silver nanoparticles (AG-AO) were characterized using UV-Spec, FTIR, XRD, TEM and SAED analysis.
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