[Methodological approaches to choosing informative laboratory biomarkers and their complexes for the early detection of the influence of harmful factors on man and for the diagnosis of occupational diseases].

Methodological approaches and strategy have been developed to choose informative laboratory biomarkers for the early and preclinical diagnosis and to detect the negative influence of harmful industrial and environmental factors. The paper considers whether the diagnostic value of laboratory tests can be defined, by studying the relationship of endogenous exposure (effect) and the proportion of subjects with the changed level of a biomarker (response) to the dose of a substance, stage of disease, and length of service. Due to the polysyndromic pattern of many occupational diseases, it is shown to be most expedient to carry out a few tests characterizing different aspects of the pathogenesis of disease. Methodological approaches to developing a set of informative biomarkers have been proposed.