AI Article Synopsis
- Biologics are effective treatments for psoriasis, especially when using an initial higher loading dose followed by a lower maintenance dose, rather than starting directly with maintenance.
- Obese patients may not respond as well to standard dosages, prompting attempts to adjust maintenance doses with varying results.
- In a study, increasing the loading dose of adalimumab for an obese psoriasis patient led to significant improvement in symptoms, suggesting this approach could be a promising alternative for patients who haven't responded to previous treatments.
Article Abstract
Biologics are highly specific and exhibit few problems in regard to overdosages. In clinical practice, induction schemes with an initial loading dose and a subsequent lower maintenance dose have been established and are of higher efficacy for psoriasis than starting directly with the maintenance dose. As obese patients sometimes respond less well to standard dosages, increases of the maintenance dose, but not the loading doses, have been tried with variable success. In our study, we increased the loading (160 mg instead of 80 mg) but not the maintenance dose of adalimumab in an obese patient with severe psoriasis resistant to previous biologics and methotrexate. Within 12 weeks, both PASI (11 to 1.6) and DLQI (22/30 to 5/30) decreased. This strategy might be an effective and less costly alternative to doubling the maintenance doses, and could be further evaluated for psoriasis patients refractory to previous treatments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128133 | PMC |
| http://dx.doi.org/10.1159/000329343 | DOI Listing |
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