A possibility of phosphatidylinositides catabolism initiation was revealed in the rat brain synaptosome membranes during in vitro action of estradiol. It was shown that appreciable enhancement of diacylglycerol yield was observed at already 5th second of initiation, which decreased then until the 30th second and kept the sufficiently high level. The yield of free arachidonic acid had also enhanced. Analogous dynamics of alteration was observed during the action of pharmacological as well as physiological concentrations of hormone.
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