A new treatment method, interception of collaterals with a silicone rubber sheet, was applied to three patients with advanced hepatocellular carcinoma in whom arterial chemoembolization was assessed as ineffective because of the developed collateral feeding arteries. This procedure was followed by arterial chemoembolization or intraportal infusion chemotherapy or both. Follow-up celiac angiography confirmed that the long-term decollateralization was achieved by shielding the liver with silicone rubber sheeting. This technique resulted in partial responses without serious complications in all the patients including two who had no responses to chemoembolization before the procedure. The response durations were 5, 21, and 27, months, respectively. One patient died of gastrointestinal bleeding 7 months after the decollateralization. The other two patients are still alive, and the survivals after the procedure are 28 and 30 months, respectively. This therapy is considered promising and may be worth choosing as an adjuvant treatment for advanced hepatic malignancies uncontrolled by arterial chemotherapy or chemoembolization.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Layer-by-Layer Self-Assembled Honeycomb Structure Flexible Pressure Sensor Array for Gait Analysis and Motion Posture Recognition with the Assistance of the ResNet-50 Neural Network.
ACS Sens
March 2025
State Key Laboratory of Chemical Safety, College of Control Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China.
With the rapid emergence of flexible electronics, flexible pressure sensors are of importance in various fields. In this study, a dopamine-modified melamine sponge (MS) was used to prepare a honeycomb structure of carbon black (CB)/MXene-silicone rubber (SR)@MS flexible pressure sensor (CMSM) through layer-by-layer self-assembly technology. Using SR as a binder to construct the honeycomb structure not only improves the mechanical properties of the sensor but also provides more attachment sites for CB/MXene, enhancing the stability of the conductive network.
View Article and Find Full Text PDF3D Printing of Silicone Organogel Elastomers for Structured Soft Biomaterials.
ACS Biomater Sci Eng
March 2025
Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.
Creating customizable soft medical implants and devices tailored to patient-specific anatomy represents a significant challenge in healthcare, requiring 3D-printable materials with viscoelastic properties similar to those of natural tissue, high adaptability, and biocompatibility. Here, we develop a family of silicone organogel inks for 3D printing of tunable soft biomaterials via direct ink writing (DIW). We have developed a set of ink formulations comprising photo-cross-linkable silicone polymers, silicone oil, and fumed silica nanoparticles to modify the rheological behavior of the inks, optimize their printability, and control the viscoelastic properties of the printed organogel materials.
View Article and Find Full Text PDFEffect of artificial aging on color change and mechanical properties of high consistency maxillofacial silicone elastomers.
J Prosthet Dent
March 2025
Professor, Department of Prosthodontics, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Statement Of Problem: Discoloration and the deterioration of mechanical properties lead to the replacement of maxillofacial prostheses. However, studies on the change in color and mechanical properties of high viscosity elastomers are lacking.
Purpose: The purpose of this in vitro study was to evaluate the influence of artificial aging on the mechanical and optical properties of high-consistency silicone elastomer (HCR) and compare these properties with a widely used liquid silicone rubber (LSR).
Electricity Driven Behavior and Self-Cleaning Property of Droplets on Superhydrophobic Anti-pollution Flashover Coating.
Langmuir
March 2025
Solar Energy High Value Utilization and Green Conversion Hubei Provincial Engineering Research Center, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, Hubei 443002, P. R. China.
The potential of superhydrophobic coatings for anti-pollution flashover should be further explored, focusing on droplet electrical behavior on surfaces. In this study, the electrically driven behavior of droplets on a horizontal superhydrophobic surface was experimentally examined. The characteristics of this behavior were compared and analyzed relative to RTV (room temperature vulcanized silicone rubber).
View Article and Find Full Text PDFInnovative Gastrointestinal Drug Delivery Systems: Nanoparticles, Hydrogels, and Microgrippers.
Front Biosci (Landmark Ed)
February 2025
Division of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
Over the past decade, new technologies have emerged to increase intrinsic potency, enhance bioavailability, and improve targeted delivery of drugs. Most pharmaceutical formulations require multiple dosing due to their fast release and short elimination kinetics, increasing the risk of adverse events and patient non-compliance. Due to these limitations, enormous efforts have focused on developing drug delivery systems (DDSs) for sustained release and targeted delivery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!