AI Article Synopsis
- The study aimed to explore the relationship between killer immunoglobulin-like receptor (KIR) gene diversity and nasopharyngeal carcinoma (NPC) in the Southern Han Chinese population.
- KIR genotyping was conducted on blood samples from 67 NPC patients and 77 healthy controls, revealing significant differences in gene frequencies.
- Specifically, KIR2DL3 was found less frequent in NPC patients, while KIR2DS5 and KIR2DL5B were more frequent, suggesting these genes could be linked to NPC development in this population.
Article Abstract
The objective of this study was to elucidate the correlation of killer immunoglobulin-like receptor (KIR) gene diversity with nasopharyngeal carcinoma (NPC) in the Chinese southern Han population. KIR genotyping of peripheral blood samples from 67 patients with NPC and 77 randomly-selected healthy controls was performed by PCR-SSP, the relative risk (RR) value was calculated by means of Wolf method. The results showed that the KIR2DL3 gene frequency in NPC patient group was significantly lower than that in healthy controls (χ²>3.84, p < 0.05, RR = 0.08), whereas the KIR2DS5 and KIR2DL5B gene frequencies in patient group were significantly higher than those in healthy controls (χ²>3.84, p < 0.05, RR > 1), the other KIR gene frequencies were no statistically different between two groups. It is concluded that the KIR2DL3, KIR2DS5 and KIR2DL5B genes may be correlated with pathogenesis of NPC in the Chinese southern Han population.
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