AI Article Synopsis
- The study examined CIAPIN1 mRNA levels in 112 newly diagnosed leukemia patients, comparing them to 10 healthy controls.
- Results showed significantly higher CIAPIN1 expression in patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic phase chronic myeloid leukemia (CML), but no difference in chronic lymphocytic leukemia (CLL) cases.
- The findings suggest that elevated CIAPIN1 expression may be linked to the development of leukemia, indicating its potential importance in the disease's pathogenesis.
Article Abstract
This study was aimed to investigate the expression level of CIAPIN1 mRNA in leukemia patients and explore its significance in leukemias. The fresh bone marrow was collected from 112 newly diagnosed leukemia patients, the total RNA was extracted by means of TRIzoL, the cDNA was synthesized, the expression of CIAPIN1 mRNA was detected by real-time quantitative PCR using β-actin as internal reference; 10 normal healthy persons were selected as controls. The results showed that the expression of CIAPIN1 mRNA was statistically higher in acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and chronic phase chronic myeloid leukemia (CML) patients than that in normal persons (p < 0.05); but there was no statistical difference between chronic lymphocytic leukemia (CLL) and normal persons (p > 0.05). It is concluded that the CIAPIN1 gene higher expresses in MNC of newly diagnosed leukemia patients, up-regulation of CIAPIN1 expression may play an important role in pathogenesis of leukemia.
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