The role of computers in dental practice has dramatically changed over the past 30 years. We have witnessed the progression from administrative roles to complete integration leading to chartless offices. As the dental community gradually adopts this contemporary development, the move to electronic health records is imminent because of upcoming changes in the health care system. The past, present, and future of dental office computer systems is explored in this article. An understanding of the benefits and current challenges of contemporary dental practice software is also reviewed.
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http://dx.doi.org/10.1016/j.cden.2011.02.010 | DOI Listing |
Commun Biol
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Epithelial-to-mesenchymal transition (EMT) is a conserved cellular process critical for embryogenesis, wound healing, and cancer metastasis. During EMT, cells undergo large-scale metabolic reprogramming that supports multiple functional phenotypes including migration, invasion, survival, chemo-resistance and stemness. However, the extent of metabolic network rewiring during EMT is unclear.
View Article and Find Full Text PDFSci Rep
December 2024
National Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand.
Inter-individual variability in drug responses is significantly influenced by genetic factors, underscoring the importance of population-specific pharmacogenomic studies to optimize clinical outcomes. In this study, we analyzed whole genome sequencing data from 949 unrelated Thai individuals and conducted an in-depth analysis of 3239 genes involved in drug pharmacokinetics, pharmacodynamics, or immune-mediated adverse drug reactions. We identified 43 single nucleotide polymorphisms (SNPs), 134 diplotypes, and 15 human leukocyte antigen (HLA) alleles, all with moderate to high clinical significance.
View Article and Find Full Text PDFArch Dis Child Fetal Neonatal Ed
December 2024
Nuffield Department of Population Health, University of Oxford National Perinatal Epidemiology Unit, Oxford, UK.
Objective: Babies born between 27 and 31 weeks of gestation contribute substantially towards infant mortality and morbidity. In England, their care is delivered in maternity services colocated with highly specialised neonatal intensive care units (NICU) or less specialised local neonatal units (LNU). We investigated whether birth setting offered survival and/or morbidity advantages to inform National Health Service delivery.
View Article and Find Full Text PDFPLoS One
December 2024
Specialized Neurological Practice, Neurological Office, Chrząstowice, Poland.
The study examines the morphometric development of the anterior cranial fossa in human fetuses and its clinical implications. The anterior cranial fossa, crucial for protecting the frontal lobes, was analyzed during prenatal development using innovative computer image processing techniques. We hypothesized that the growth of the anterior cranial fossa is not uniform throughout fetal development and that changing geometric relationships are important for possible therapeutic interventions in cases of congenital defects.
View Article and Find Full Text PDFMetabolites
December 2024
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 61922, Saudi Arabia.
TCIPP (tris(1,3-dichloro-2-propyl) phosphate) and TCEP (tris(2-chloroethyl) phosphate) are organophosphate ester flame retardants found in various consumer products, posing significant health and environmental risks through inhalation, ingestion, and dermal exposure. Research reveals these compounds cause oxidative stress, inflammation, endocrine disruption, genotoxicity, neurotoxicity, and potentially hepatotoxicity, nephrotoxicity, cardiotoxicity, developmental, reproductive, and immunotoxicity. This review summarizes the current knowledge on the toxicological mechanisms of TCIPP and TCEP and presents the latest data on their toxicological effects obtained in vitro and in vivo, using omic systems, and on the basis of computational modelling.
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