A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c1cc12495a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correction: Camptothecin-based prodrug nanomedicines for cancer therapy.
Nanoscale
January 2025
Cancer Institute of The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, China.
Correction for 'Camptothecin-based prodrug nanomedicines for cancer therapy' by Renshuai Zhang , , 2023, , 17658-17697, https://doi.org/10.1039/D3NR04147F.
View Article and Find Full Text PDFSpatiotemporal-controllable ROS-responsive camptothecin nano-bomb for chemo/photo/immunotherapy in triple-negative breast cancer.
J Nanobiotechnology
December 2024
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Chemotherapy is still one of the major approaches in triple-negative breast cancer (TNBC) treatment. The development of new formulations for classic chemotherapeutic drugs remains interests in studies. Camptothecin (CPT) is powerful antitumor agents in TNBC treatment though its clinic applications are limited by its low water solubility and systemic toxicity.
View Article and Find Full Text PDFCascade-Activatable Nanoprodrug System Augments Sonochemotherapy of Bladder Cancer.
ACS Nano
December 2024
NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Heilongjiang Key Laboratory of Scientific Research in Urology, Harbin Medical University, Harbin 150001, China.
Sonochemotherapy (SCT) has emerged as a powerful modality for cancer treatment by triggering excessive production of reactive oxygen species (ROS) and controlled release of chemotherapeutic agents under ultrasound. However, achieving spatiotemporally controlled release of chemotherapeutic agents during ROS generation is still an enormous challenge. In this work, we developed a cascade-activated nanoprodrug () system that utilizes a reversible covalent Schiff base mixed with a hypoxia-activatable camptothecin (CPT) prodrug.
View Article and Find Full Text PDFSequential self-assembly and release of a camptothecin prodrug for tumor-targeting therapy.
Nanoscale
December 2024
Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
Article Synopsis
- Chemotherapy is a common yet problematic cancer treatment due to issues like poor drug solubility, stability, and drug resistance that lead to limited effectiveness and severe side effects.
- Researchers are exploring innovative combinations of therapies, focusing on targeted therapy, prodrug design, and drug delivery to create improved treatments, such as a self-assembled camptothecin (CPT) prodrug known as CPT-SS-FFEYp-Biotin.
- This prodrug enhances the therapeutic effects on tumor cells while minimizing harm to normal cells, demonstrating greater efficacy and safety, and suggesting potential for developing more prodrugs for effective cancer treatments in the future.
Self-assembled free nanocarrier prodrugs based on camptothecin and dihydroartemisinin exhibit accumulation and improved anticancer efficacy.
Biotechnol Appl Biochem
December 2024
Department of Chemistry, CHRIST (Deemed to be University), Bangalore, Karnataka, India.
Small molecule targeted inhibitor therapies often have several drawbacks, including limited oral bioavailability, quick metabolism, toxic effects that limit dosage, and poor water solubility. This study aims to develop a nanodrug self-delivery system that does not require a carrier by utilizing the self-assembly of camptothecin (CPT) and dihydroartemisinin (DHA). CPT/DHA nanoparticles (NPs) with varying diameters can be synthesized without requiring further carrier materials or chemical modifications by changing the CPT-to-DHA ratio (10:1, 5:1, 2:1, 1:1).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!