High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes.

J Neural Eng

Bioelectronic Systems Lab, Department of Electrical Engineering, Columbia University, 500 West 120th Street 1300, New York, NY, USA.

Published: August 2011

We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65,000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm(-2). We demonstrate extracellular stimulation of dispersed primary hippocampal neuronal cultures using the chip at single-cell resolution.

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http://dx.doi.org/10.1088/1741-2560/8/4/044003DOI Listing

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