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Unlabelled: Mild hypoxic-ischemic encephalopathy is common in neonates with no evidence-based therapies, and 30-40% of patients experience adverse outcomes. The nature and progression of mild injury is poorly understood. Thus, we studied the evolution of mild perinatal brain injury using longitudinal two-photon imaging of transgenic fluorescent proteins as a novel readout of neuronal viability and activity at cellular resolution.
View Article and Find Full Text PDFWhile pancreatic beta-cell proliferation has been extensively studied, the role of cell death during islet development remains incompletely understood. Using a genetic model of caspase inhibition in beta cells coupled with mathematical modeling, we here discover an onset of beta-cell death in juvenile zebrafish, which regulates beta-cell mass. Histologically, this beta-cell death is underestimated due to phagocytosis by resident macrophages.
View Article and Find Full Text PDFOutcomes for older patients with subarachnoid haemorrhage who require admission to an Australian intensive care unit.
J Intensive Care Soc
December 2024
Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Background: Advanced age is an independent risk factor for poor outcomes following aneurysmal subarachnoid haemorrhage (SAH). However, Australian data are lacking. Our aim was to evaluate outcomes for older patients admitted to an Australian intensive care unit for management of aneurysmal SAH.
View Article and Find Full Text PDFMicroglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.
PLoS Biol
October 2024
Department of Biological Sciences at the University of Notre Dame, Notre Dame, Indiana, United States of America.
The overproduction of cells and subsequent production of debris is a universal principle of neurodevelopment. Here, we show an additional feature of the developing nervous system that causes neural debris-promoted by the sacrificial nature of embryonic microglia that irreversibly become phagocytic after clearing other neural debris. Described as long-lived, microglia colonize the embryonic brain and persist into adulthood.
View Article and Find Full Text PDFImpact of the Charlson Comorbidity Index on Delirium Outcomes.
Cureus
September 2024
Department of Geriatrics, Hackensack University Medical Center, Hackensack, USA.
Introduction Delirium is a significant inpatient healthcare challenge and has a greater incidence among older adults with adverse healthcare outcomes. Yet there are limited established models for risk stratification. The objective is to determine the effectiveness of implementing the Charlson comorbidity index (CCI) score, which is calculated based on the assigned weight for various disease conditions, and to analyze the healthcare outcomes in older hospitalized adults with delirium.
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