AI Article Synopsis
Article Abstract
Microsatellites are common and play diverse roles in eukaryotic and prokaryotic genomes. However, to our knowledge, microsatellite distribution remains largely enigmatic in viruses yet is crucial for understanding instability of viral genomes. We have therefore, examined microsatellite distribution in 54 complete genomes of Hepatitis C virus (HCV) from six genotypes, showing microsatellites were an important component of HCV genomes. Our results showed, in all analyzed HCV genomes, genome size and GC content had a weak influence on number, relative abundance and relative density of microsatellites, respectively. For each HCV genome, mono-, di- and trinucleotide repeats were very predominant, whereas other types of repeats rarely occurred. Our results revealed that the occurrence of microsatellites was significantly less than higher prokaryotes and eukaryotes and that all identified microsatellites were very short. The discovery of microsatellites in HCV genomes may become useful for population genetic, evolutionary analysis and strain (isolate) identification.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.meegid.2011.06.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A diet-wide association study for liver cancer risk: findings from a prospective cohort study in Chinese women.
J Nutr Sci
December 2024
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Although dietary factors have been examined as potential risk factors for liver cancer, the evidence is still inconclusive. Using a diet-wide association analysis, our research evaluated the associations of 126 foods and nutrients on the risk of liver cancer in a Chinese population. We obtained the diet consumption of 72,680 women in the Shanghai Women's Health Study using baseline dietary questionnaires.
View Article and Find Full Text PDFGlobal Origin and Spatiotemporal Spread of Hepatitis C Virus Epidemic Genotypes/Subtypes: A Complete Genome-Based Phylodynamic and Phylogeographic Analyses.
J Med Virol
December 2024
Virology Unit and Bioinformatics Centre, Institute of Microbial Technology (IMTECH), Council of Scientific and Industrial Research (CSIR), Chandigarh, India.
Hepatitis C virus (HCV) is a pathogenic virus of global health concern. The phylodynamics of HCV genotypes/subtypes 1a, 1b, 2, and 3 are explored only for specific geographic regions. However, their genome based global origin and detailed spatiotemporal spread, have yet to be extensively studied.
View Article and Find Full Text PDFFrequencies of an Variant in an Admixed Population from Amazonia and Its Influence on Hepatitis C Infection.
Int J Mol Sci
November 2024
Laboratory of Human and Medical Genetics, Federal University of Pará, Belém 66073-000, Brazil.
The rs12979860 polymorphism, related to the gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of this variant in an Amazonian population from Brazil, as well as its association with liver fibrosis development and its staging in HCV carriers. Our results show a significant association of the TT genotype in the sample of patients with HCV (OR = 2.
View Article and Find Full Text PDFM2BPgs-HCC: An Automated Multilectin Bead Array Indicating Aberrant Glycosylation Signatures Toward Hepatitis C Virus-Associated Hepatocellular Carcinoma Prognosis.
Molecules
November 2024
Molecular & Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science & Technology, Tsukuba 305-8565, Japan.
Regular monitoring of patients with a history of hepatitis C virus (HCV) infection is critical for the detection and management of hepatocellular carcinoma (HCC). Mac-2 binding protein glycosylation isomer (M2BPGi) has been used to monitor fibrosis progression and predict HCC. However, HCC prediction based on M2BPGi has not been optimized.
View Article and Find Full Text PDFDetection of a novel hepacivirus in wild cavies (Cavia aperea aperea).
Arch Virol
December 2024
Laboratório de Imunologia e Biologia Molecular, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Article Synopsis
- Hepacivirus is an RNA virus genus, with hepatitis C virus (HCV) being the most well-known member, and various hepaciviruses have been found in different rodent species.
- A new potential genotype of an unclassified rodent hepacivirus was discovered in a wild cavy, indicating that this virus can cross species boundaries, as it was previously identified in a different rodent species.
- The study's findings, which include complete genome sequencing, could help researchers understand the evolutionary origins of HCV and identify potential virus reservoirs related to human pathogens.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!