Objective: To examine the clinical utility of noncontrast-enhanced computed tomography (NCCT) in pediatric patients with urolithiasis who progressed to surgery. Although NCCT is routine for the evaluation of adult patients with suspected urolithiasis, its routine use in the pediatric population is tempered by concern about radiation exposure.
Methods: We conducted a retrospective chart review of all pediatric patients who had undergone surgery for urinary stones from 2003 to 2008 at our institution. The imaging modalities used, surgery type, stone composition, 24-hour urinalyses, and relevant predisposing conditions were characterized.
Results: A total of 42 pediatric patients (24 males and 18 females) were treated during the 6-year period. The average age was 11.3±5.3 years (range 2.7-25.4), and the most common treatment modalities were shock wave lithotripsy (28%) and ureteroscopy (22%). A discernible risk factor or cause of urolithiasis was absent in 21 patients (47%). A review of imaging studies found 38 with stones visible on ultrasonography and/or abdominal plain film. A total of 21 patients underwent NCCT, in addition to ultrasonography and/or abdominal plain film. Of these, only 5 patients required NCCT for the diagnosis or management of their stone.
Conclusion: Nearly 90% of pediatric patients treated for symptomatic urolithiasis could have completed their evaluation and treatment without undergoing NCCT. For children who present with signs and symptoms suggesting urinary calculi, an initial evaluation and imaging with ultrasonography and abdominal plain film might suffice, avoiding the radiation of NCCT.
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http://dx.doi.org/10.1016/j.urology.2011.02.062 | DOI Listing |
Pediatr Surg Int
December 2024
Department of Pediatric Critical Care, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.
Background: Burns in children are often complex injuries, leading to prolonged length of stay (LOS) and significant morbidity. LOS in pediatric intensive care units (PICUs) is a key measure for evaluating illness severity, clinical outcomes, and quality of care. Accurate prediction of LOS is vital for improving care planning and resource allocation.
View Article and Find Full Text PDFChilds Nerv Syst
December 2024
Department of Children's and Adolescence Health, Division of Neuropediatrics, University Hospital Leipzig, Leipzig, Germany.
Introduction: Endoscopic Third Ventriculostomy (ETV) is a well-established treatment for pediatric hydrocephalus, particularly in cases of aqueductal stenosis. The ETV Success Score (ETVSS) is a predictive tool widely used to estimate the likelihood of ETV success based on factors like age. Its accuracy, especially in infants under 3 months, is still debated.
View Article and Find Full Text PDFVirulence
December 2025
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Amino acid metabolism provides significant insight into the development and prevention of many viral diseases. Therefore, the present study aimed to compare the amino acid profiles of hand, foot, and mouth disease (HFMD) patients with those of healthy individuals and to further reveal the molecular mechanisms of HFMD severity. Using UPLC-MS/MS, we determined the plasma amino acid expression profiles of pediatric patients with HFMD (mild, = 42; severe, = 43) and healthy controls ( = 25).
View Article and Find Full Text PDFGenet Med
December 2024
Movement Disorders Program, Department of Neurology and F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Objectives: Biallelic HPDL variants have been identified as the cause of a progressive childhood-onset movement disorder, with a broad clinical spectrum from severe neurodevelopmental disorder to juvenile-onset pure hereditary spastic paraplegia type 83. This study aims at delineating the geno- and phenotypic spectra of patients with HPDL-related disease, quantitatively modelling the natural history, and uncovering genotype-phenotype associations.
Methods: A cross-sectional analysis of 90 published and one novel case was performed, employing a Human Phenotype Ontology-based approach.
Clin Pharmacol Ther
December 2024
Department of Pharmacy, Uppsala University, Uppsala, Sweden.
The complexity of the currently registered dosing schedules for bedaquiline and delamanid is a barrier to uptake in drug-resistant tuberculosis treatment across all ages. A simpler once-daily dosing schedule is critical to ensure patient-friendly regimens with good adherence. We assessed expected drug exposures with proposed once-daily doses for adults and compared novel model-informed once-daily dosing strategies for children with current World Health Organization (WHO) recommended dosing.
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