Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/13623699.2011.562392 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Medical professionals' resistance against the arms race and nuclear weapons.
Indian J Med Ethics
February 2024
Former Co-President, International Physicians for the Prevention of Nuclear War, and President, Indian Doctors for Peace and Development, 139-E, Kitchlu Nagar, Ludhiana - 141001, Punjab, INDIA.
The atomic bombing of Hiroshima and Nagasaki 78 years ago changed the concept of the impact of wars. The hope that the level of devastation would make the world think seriously about taking steps to give up the arms race and focus on human welfare did not materialise. The arms race continues unabated.
View Article and Find Full Text PDFRRM1 and PAB domains of translation initiation factor eIF4G (Tif4631p) play a crucial role in the nuclear degradation of export-defective mRNAs in Saccharomyces cerevisiae.
FEBS J
March 2024
Department of Life Science and Biotechnology, Jadavpur University, Kolkata, India.
In Saccharomyces cerevisiae, the CBC-Tif4631p-dependent exosomal targeting (CTEXT) complex consisting of Cbc1/2p, Tif4631p and Upf3p promotes the exosomal degradation of aberrantly long 3'-extended, export-defective transcripts and a small group of normal (termed 'special') mRNAs. We carried out a systematic analysis of all previously characterized functional domains of the major CTEXT component Tif4631p by deleting each of them and interrogating their involvement in the nuclear surveillance of abnormally long 3'-extended and export-defective messages. Our analyses show that the N-terminal RNA recognition motif 1 (RRM1) and poly(A)-binding protein (PAB) domains of Tif4631p, spanning amino acid residues, 1-82 and 188-299 in its primary structure, respectively, play a crucial role in degrading these aberrant messages.
View Article and Find Full Text PDF1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in T17 cells.
Sci Immunol
August 2023
AMED-CREST, AMED, Tokyo, Japan.
Metabolic fluxes involving fatty acid biosynthesis play essential roles in controlling the differentiation of T helper 17 (T17) cells. However, the exact enzymes and lipid metabolites involved, as well as their link to promoting the core gene transcriptional signature required for the differentiation of T17 cells, remain largely unknown. From a pooled CRISPR-based screen and unbiased lipidomics analyses, we identified that 1-oleoyl-lysophosphatidylethanolamine could act as a lipid modulator of retinoid-related orphan receptor gamma t (RORγt) activity in T17 cells.
View Article and Find Full Text PDFMembrane estrogen receptor-α contributes to female protection against high-fat diet-induced metabolic disorders.
Front Endocrinol (Lausanne)
August 2023
Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)/Université Paul Sabatier (UPS), Université Toulouse 3, Toulouse, France.
Background: Estrogen Receptor α (ERα) is a significant modulator of energy balance and lipid/glucose metabolisms. Beyond the classical nuclear actions of the receptor, rapid activation of intracellular signaling pathways is mediated by a sub-fraction of ERα localized to the plasma membrane, known as Membrane Initiated Steroid Signaling (MISS). However, whether membrane ERα is involved in the protective metabolic actions of endogenous estrogens in conditions of nutritional challenge, and thus contributes to sex differences in the susceptibility to metabolic diseases, remains to be clarified.
View Article and Find Full Text PDFGut microbial fatty acid isomerization modulates intraepithelial T cells.
Nature
July 2023
Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
The human gut microbiome constantly converts natural products derived from the host and diet into numerous bioactive metabolites. Dietary fats are essential micronutrients that undergo lipolysis to release free fatty acids (FAs) for absorption in the small intestine. Gut commensal bacteria modify some unsaturated FAs-for example, linoleic acid (LA)-into various intestinal FA isomers that regulate host metabolism and have anticarcinogenic properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!