The goal of the study was to determine morphological changes of conjunctiva underlying positive vital staining in TED. 46 patients (92 eyes) with TED were included into the study. Besides routine ophthalmologic examination they underwent impression cytology and histology. According to our results positive conjunctival staining in TED is caused by punctuate epithelial erosions and excessive desquamation of superficial cells. Revealed changes are not specific for TED.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Stimulation of Piezo1 mechanosensitive channels inhibits adipogenesis in thyroid eye disease.
J Clin Endocrinol Metab
January 2025
Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Address: Hungary, 4032 Debrecen Nagyerdei krt. 98. Tel. +36-52-255-600.
Context: Increased orbital tissue volume due to matrix expansion, orbital fibroblast (OF) proliferation and adipocyte differentiation are the hallmarks of thyroid eye disease (TED). Their combination with the presence of hyaluronan-bound excess water in the constrains of the bony orbit results in increased intraorbital pressure. High intraorbital pressure, along with changes in the mechanical properties of orbital tissues, may lead to the activation of mechanosensitive receptors.
View Article and Find Full Text PDF[Effect of Zhishi Xiebai Guizhi Decoction on phenotypic transformation of pulmonary artery smooth muscle cells in rats with hypoxic pulmonary hypertension].
Zhongguo Zhong Yao Za Zhi
October 2024
Qinghai University Xining 810001, China Research Center for High Altitude Medicine, Medical College, Qinghai University Xining 810001, China.
This study aims to investigate the effect of Zhishi Xiebai Guizhi Decoction on the phenotypic transformation of pulmonary artery smooth muscle cells(PASMCs) in rats with hypoxic pulmonary hypertension(HPH). Healthy SPF SD rats were randomly assigned to five groups: control group, hypoxia model group, hypoxia + low-dose Zhishi Xiebai Guizhi Decoction group(440 mg·kg~(-1)·d~(-1)), hypoxia + high-dose Zhishi Xiebai Guizhi Decoction group(880 mg·kg~(-1)·d~(-1)), and hypoxia + sildenafil group(30 mg·kg~(-1)·d~(-1)), with right rats in each group. Rats in the hypoxia model and hypoxia + drug groups were exposed to a hypobaric oxygen chamber with a simulated altitude of 5 000 m to induce the PH model.
View Article and Find Full Text PDF2'-O-Galloylhyperin Prevents Tissue Remodeling in Thyroid Eye Disease: Prospects as a Thyrotropin Receptor Antagonist.
J Clin Endocrinol Metab
December 2024
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Context: Thyroid eye disease (TED) is a challenging condition owing to relentless orbital tissue remodeling, with thyrotropin receptor (TSHR) in orbital fibroblasts (OFs) serving as a promising therapeutic target.
Objective: This study seeks to discover potential TSHR inhibitors among US Food and Drug Administration (FDA)-approved drugs and evaluate their effects on TED-OFs.
Methods: Adipose tissues were sourced from the patients with or without TED.
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Mol Neurodegener
November 2024
Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Article Synopsis
- - Variants in the CTSB gene are linked to an increased risk of Parkinson's disease (PD) and affect the activity of cathepsin B, an enzyme involved in breaking down proteins and regulating cellular processes related to autophagy and lysosome function.
- - CatB can both degrade the harmful alpha-synuclein protein associated with PD and potentially create shorter versions of it that are more prone to aggregation, complicating its role in PD pathology.
- - Experiments showed that inhibiting catB disrupts autophagy and lysosomal function, leading to an accumulation of toxic protein aggregates, while activating catB enhances the clearance of these aggregates in cell and neuron models.
miR-101-3p suppresses proliferation of orbital fibroblasts by targeting pentraxin-3 in thyroid eye disease.
PeerJ
November 2024
Department of Ophthalmology, Changzheng Hospital of Naval Medical University, Shanghai, China.
Article Synopsis
- - The study investigates the role of miR-101-3p in the proliferation of orbital fibroblasts in thyroid eye disease (TED) and seeks to identify its targets, particularly focusing on pentraxin-3 (PTX3).
- - Research methods involved harvesting orbital adipose tissues from TED patients and control subjects, followed by various assays to assess fibroblast proliferation and apoptosis after manipulating miR-101-3p levels.
- - Results showed that miR-101-3p is downregulated in TED, and its overexpression inhibits fibroblast proliferation by targeting PTX3, enhancing understanding of TED's pathological mechanisms.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!