AI Article Synopsis
- Kaempferia parviflora (KP) is a Thai medicinal plant traditionally used for treating various ailments, including pain and gastrointestinal issues.
- The study found that an extract from KP rhizomes demonstrated significant inhibition of xanthine oxidase (XOD), surpassing other Zingiberaceae plants in effectiveness.
- Researchers isolated ten methoxyflavones from KP, with two specific compounds showing notable XOD inhibitory activities, marking the first documentation of KP and these compounds' effects on XOD.
Article Abstract
Kaempferia parviflora (KP), a Zingiberaceae plant, is used as a folk medicine in Thailand for the treatment of various symptoms, including general pains, colic gastrointestinal disorders, and male impotence. In this study, the inhibitory activities of KP against xanthine oxidase (XOD) were investigated. The extract of KP rhizomes showed more potent inhibitory activity (38% at 500 µg/ml) than those of the other Zingiberaceae plants tested. Ten methoxyflavones were isolated from the KP extract as the major chemical components and their chemical structures were elucidated by X-ray crystallography. The structurally confirmed methoxyflavones were subjected to the XOD inhibitory test. Among them, 3,5,7,4',5'-pentamethoxyflavone and 3',4',5,7-tetramethoxyflavone showed inhibitory activities (IC(50) of 0.9 and >4 mM, respectively) and their modes of inhibition are clarified as competitive/non-competitive mixed type. To the best of our knowledge, this is the first report to present the inhibitory activities of KP, 3,5,7,4',5'-pentamethoxyflavone and 3',4',5,7-tetramethoxyflavone against XOD.
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| http://dx.doi.org/10.1248/bpb.34.1143 | DOI Listing |
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