The present study was aimed to evaluate the immunogenicity of a single dose of conjugate Meningococcus C (Men C) vaccine by analyzing the serum bactericidal antibody (SBA) titers in 10 pediatric solid organ transplant (SOT) patients. Four patients showed a delayed immune response after 1 month, but all patients demonstrated an increase of SBA titers after vaccination. A significant decrease of SBA titers was seen after 6 months. However, all patients maintained protective SBA titers (≥1:8) despite rapidly waning titers. For patients with significantly decreasing titers, a booster dose may be discussed with close monitoring of SBA titers over time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vaccine.2011.06.033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long term T cell response and safety of a tetravalent dengue vaccine in healthy children.
NPJ Vaccines
October 2024
Takeda Pharmaceuticals International AG, Zurich, Switzerland.
As robust cellular responses are important for protection against dengue, this phase 2 study evaluated the kinetics and phenotype of T cell responses induced by TAK-003, a live-attenuated tetravalent dengue vaccine, in 4-16-year-old living in dengue-endemic countries (NCT02948829). Two hundred participants received TAK-003 on Days 1 and 90. Interferon-gamma (IFN-γ) enzyme-linked immunospot assay [ELISPOT] and intracellular cytokine staining were used to analyze T cell response and functionality, using peptide pools representing non-structural (NS) proteins NS3 and NS5 matching DENV-1, -2, -3, and -4 and DENV-2 NS1.
View Article and Find Full Text PDFCharacterisation and Immunogenicity of outer membrane vesicles displaying NadA, NHBA and fHbp from serogroup B.
Front Immunol
October 2024
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Article Synopsis
- There is a need for more affordable and effective vaccines to prevent bacterial meningitis caused by serogroup B globally.
- The study explores the use of modified outer membrane vesicles (mOMVs) from commensal bacteria to elicit immune responses against meningococcal antigens, specifically various versions of factor H binding protein, Heparin Binding Antigen, and Adhesin A.
- The results showed that mice immunized with these engineered mOMVs produced antibodies to all targeted antigens and demonstrated significant serum bactericidal activity, indicating the potential of mOMVs for developing a protective vaccine against meningococcal disease.
Refinement and optimisation of Neisseria gonorrhoeae NHBA and MetQ vaccine candidates.
Vaccine
December 2024
Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD, Australia. Electronic address:
Article Synopsis
- * This study explored two vaccine candidates, cNHBA and MetQ, aiming to enhance their immune response by creating fusions with MetQ protein fragments, using aluminium hydroxide as an adjuvant for better vaccine production and efficacy.
- * Results showed that these fusions triggered strong immune responses in mice, leading to significant bacterial killing and a reduction in bacterial adherence, identifying MetQ-cNHBA and cNHBA-Met2 as the most promising candidates for future vaccine development against gonorr
Policies for the immunization against serogroup B meningococcus for adolescents immunized during the first two years of life: A mini review.
Hum Vaccin Immunother
December 2024
Interdisciplinary Department of Medicine, Hygiene Unit, University of Bari Aldo Moro, Bari, Italy.
Article Synopsis
- There are two vaccines available to prevent serogroup B meningococcal disease: 4CMenB, which is part of routine infant immunizations, and MenB-fHbp.
- Immunogenicity data indicates that while protective antibody levels initially rise after vaccination, they decline over time, with a booster dose helping to restore levels initially.
- Current evidence suggests that a booster for adolescents who were vaccinated in infancy may not provide long-lasting protection, and revaccination might be necessary instead.
Bactericidal Activity of Serum by RB51 Outer Membrane Protein's Combined by S99 Lipopolysaccharide Induction.
Avicenna J Med Biotechnol
January 2024
Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran-North Branch, Tehran, Iran.
Background: Brucellosis vaccines are designed to induce cellular immunity. An effective brucellosis vaccine could induce both cellular and humoral immunity. Serum Bactericidal Assay (SBA) is an important method for determining vaccine humoral immunity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!