AI Article Synopsis
- The study investigates how ursolic acid (UA) affects the growth of gastric cancer cells (BGC-803) and liver cancer cells (H22) to understand its mechanisms.
- UA inhibits BGC-803 cell growth in a time- and dose-dependent manner, leading to increased apoptosis and cell cycle arrest at the G0/G1 stage.
- The findings show that UA promotes cell death by activating specific caspases and reducing Bcl-2, indicating its potential as an effective treatment for these cancer cell lines.
Article Abstract
The aims of the study are to explore the effect of ursolic acid (UA) on the growth of gastric cancer cell line BGC-803 and hepatocellular cancer cell H22 xenograft and to understand the mechanism. UA inhibits growth of BGC-803 cells in vitro in dose-dependent and time-dependent manner. Treated with UA in vivo, tumor cells can be arrested to G0/G1 stage. The apoptotic rate was significantly increased in tumor cells treated with UA both in vitro and in vivo. DNA fragmentation was found in BGC-803 cells exposed to UA. UA activated caspase-3, -8, and -9 and down regulated expression of Bcl-2 in BGC-803 cells. The expression of caspase-3 and -8 was elevated in tumor cells from xenograft treated with UA. ¹⁸F-FLT PET-CT imaging confirmed tumor model and UA effectiveness. Our results indicated that UA inhibits growth of tumor cells both in vitro and in vivo by decreasing proliferation of cells and inducing apoptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116524 | PMC |
| http://dx.doi.org/10.1155/2011/419343 | DOI Listing |
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