Introduction: Consumption of large amounts of alcohol can promote regurgitation of hydrochloric acid into the esophagus and therefore cause symptoms of gastroesophageal reflux disease. Most individuals who experience alcohol-related health problems are not addicted to alcohol, but they usually show a hazardous pattern of alcohol consumption.
Objectives: Objectives The aim of the study was to examine the gastrointestinal tract in hazardous drinkers and to establish whether such alcohol consumption pattern may be an important risk factor for developing gastroesophageal reflux.
Patients And Methods: Primary care patients (n = 2000; mean age 41.1 years) from Warsaw, Poland, responded to 2 surveys: AUDIT (Alcohol Use Disorders Identification Test) and Carlsson's questionnaire. Patients characterized as hazardous drinkers and having symptoms of reflux disease entered the second phase of the study: gastroscopy and pH-metry. The results were compared with those obtained in the control group (n = 60), which included patients with reflux symptoms but who abstained from alcohol or were moderate drinkers.
Results: According to the survey results, 18.75% of the study group showed a hazardous pattern of alcohol consumption, while 33% had symptoms of gastrointestinal reflux disease. A positive pH-metry result was observed in 87.5% of the hazardous drinkers. Endoscopic features of esophagitis were observed in 64% of the patient group and 28% of the control group. Hazardous alcohol consumption and male sex may be the risk factors for developing reflux-related esophagitis.
Conclusions: Primary care physicians should routinely ask their patients about alcohol consumption. Hazardous alcohol drinking may be a risk factor for developing reflux disease.
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Clin Chim Acta
March 2025
Department of Medicine, Hunan University of Arts and Science, Changde, Hunan Province 415000, China.
Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with increasing incidence and poor survival rates, primarily due to late-stage diagnosis. This cancer often develops from Barrett's Esophagus (BE), a precancerous condition linked to chronic gastroesophageal reflux disease (GERD). The transition from BE to EAC is a complex multistep process involving numerous genetic, epigenetic, and molecular changes that lead to the malignant transformation of the esophageal epithelium.
View Article and Find Full Text PDFJ Affect Disord
March 2025
Department of Thoracic Surgery, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215101, China. Electronic address:
Background: This study seeks to elucidate the association between depression and the risk of chronic obstructive pulmonary disease (COPD) by Mendelian randomization (MR) analysis, motivated by prior observational studies indicating a potential link between these conditions.
Methods: Data from individuals of European (EUR) and East Asian (EAS) ancestries diagnosed with major depressive disorder (MDD) were selected for analysis. The primary method utilized was inverse variance weighted (IVW) method, supplemented by a series of sensitivity analyses and false discovery rate (FDR) corrections.
ANZ J Surg
March 2025
Department of Surgery, University of Notre Dame Australia, Sydney, New South Wales, Australia.
Background: Gastroesophageal reflux disease (GORD) is a significant problem after laparoscopic sleeve gastrectomy (SG). This study aimed to assess the long-term effect of SG with an anterior fundoplication on GORD symptoms.
Methods: A single-centre cohort study of all patients who underwent SG with anterior hemifundoplication (SGAF), with a 2:1 SG only comparison group.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Pillaiyarkuppam, Pondicherry, 607402 India.
Laryngopharyngeal reflux disease (LPRD) is characterized by the backflow of gastric contents into the laryngopharynx, distinct from gastroesophageal reflux disease (GERD). Prevalence among otolaryngology patients ranges from 4 to 30% and being the major cause for hoarseness of voice. Common symptoms include hoarseness, chronic coughing, globus sensation, throat clearing and endoscopic evaluation reveals signs like posterior commissure hypertrophy and vocal fold edema.
View Article and Find Full Text PDFJ Formos Med Assoc
March 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, An Nan Hospital, China Medical University, Tainan, Taiwan. Electronic address:
Background: Whether continuous proton pump inhibitor (PPI) therapy is superior to on-demand therapy for symptom control of Barrett's esophagus patients is unclear. The study aimed to compare the efficacies of the symptom control and the frequency of co-existent erosive esophagitis in patients with Barrett's esophagus by either continuous or on-demand PPI therapy.
Methods: We randomly assigned (1:1) consecutive adult patients with symptomatic Barrett's esophagus to receive on-demand or continuous esomeprazole (40 mg q.
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