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Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis.
Lancet Child Adolesc Health
February 2025
Stellenbosch University, Faculty of Medicine and Health Sciences, Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Tygerberg, South Africa.
Background: There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially with more recently available drugs and regimens. We aimed to describe the clinical and treatment characteristics and their associations with treatment outcomes in this susceptible population.
Methods: We conducted a systematic review and individual participant data meta-analysis.
Under-five mortality and social determinants in africa: a systematic review.
Eur J Pediatr
January 2025
Global Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, Lisbon, Portugal.
Purpose: Under-five mortality is a key public health indicator, highly responsive to preventive interventions. While global efforts have made strides in reducing mortality rates in this age group, significant disparities persist, particularly in Sub-Saharan Africa. This study aimed to systematically review the factors influencing under-five mortality in Africa, focusing on sociodemographic factors and health-related determinants.
View Article and Find Full Text PDFCommunity responses to a novel house design: A qualitative study of "Star Homes" in Mtwara, southeastern Tanzania.
PLoS One
January 2025
Amsterdam University Medical Centres, University of Amsterdam, Department of Global Health, Amsterdam, The Netherlands.
Introduction: To evaluate the impact of a novel design "Star Home" on the incidence of malaria, respiratory tract infections and diarrheal diseases among children, randomly selected households in Mtwara, Tanzania were offered a free, new Star Home. Drawing on longitudinal qualitative research that accompanied the Star Homes study, this article describes the experiences of residents and the wider community of living with these buildings.
Methods: A total of four rounds of face-to-face interviews were undertaken with residents of Star Homes (n = 37), control (wattle/daub) homes (n = 21), neighboring households n = 6), community members (n = 17) and community leaders (n = 6).
Predictors of insecticide-treated nets utilization among children under five years in refugee settlements in Uganda: analysis of the 2018-2019 Uganda Malaria Indicator Survey.
Malar J
January 2025
Department of Geography, Geo-Informatics and Climatic Sciences, Makerere University, P.O Box 7062, Kampala, Uganda.
Background: Despite significant distribution of insecticide-treated net (ITNs) by the Government of Uganda to refugees, malaria is major cause of mortality and morbidity among children under five years in refugee settlements. This highlights the persistent challenges and complexities surrounding malaria control and prevention efforts in these settings. Studies that focus on the determinants of ITN utilization among children under five years in refugee settlements in Uganda are not available.
View Article and Find Full Text PDFMortality among 5 to 19-year-olds in rural Mali.
PLOS Glob Public Health
January 2025
Institute for Health & Aging, School of Nursing, University of California, San Francisco, San Francisco, California, United States of America.
The unique healthcare needs of 5 to 9-year-olds and adolescents (10-19 years) in low- and middle-income countries have been largely neglected. We generated estimates of 5 to 9-year-old and adolescent mortality in rural Mali, a setting with high under-five mortality, and aimed to define associated individual and household risk factors. We analysed cross-sectional baseline household survey data from the ProCCM trial (NCT02694055) conducted in Bankass District, Mali collected in December 2016 and January 2017.
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