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Investigation of the anti-Huanglongbing effects using antimicrobial lipopeptide and phytohormone complex powder prepared from MG-2 fermentation.
Front Microbiol
December 2024
National Key Laboratory of Germplasm Innovation and Utilization of Horticultural Crops, National Fruit Free-Virus Germplasm Resource Indoor Conservation Center, Department of Horticulture and Forestry, Huazhong Agricultural University, Wuhan, China.
Global citrus production has been severely affected by citrus Huanglongbing (HLB) disease, caused by Candidatus Liberibacter asiaticus (Clas), and the development of effective control methods are crucial. This study employed antimicrobial lipopeptide and phytohormone complex powder (L1) prepared from the fermentation broth of the endophytic plant growth promoting bacterium (PGPB) of strain MG-2 to treat Liberibacter asiaticus (Las)-infected ' 'Chun Jian' plants. Real-time fluorescence quantitative polymerase chain reaction (qPCR) and PCR were employed for disease detection.
View Article and Find Full Text PDFZ-Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis.
Immunol Rev
January 2025
Department of Biochemistry, Division of Biological Sciences, Indian Institute of Science, Bengaluru, Karnataka, India.
Z-nucleic acid binding protein 1 (ZBP1) is an innate immune sensor recognizing nucleic acids in Z-conformation. Upon Z-nucleic acid sensing, ZBP1 triggers innate immune activation, inflammation, and programmed cell death during viral infections, mice development, and inflammation-associated diseases. The Zα domains of ZBP1 sense Z-nucleic acids and promote RIP-homotypic interaction motif (RHIM)-dependent signaling complex assembly to mount cell death and inflammation.
View Article and Find Full Text PDFInhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung.
Nat Commun
January 2025
Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.
Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@cGAMP) to remodel the tumor microenvironment and thereby enhance CAR-T cell activity. Following pulmonary delivery, the nanovesicles rapidly accumulate in the lung and selectively deliver STING agonists to PD-L1-overexpressing cells via the PD-1/PD-L1 interaction.
View Article and Find Full Text PDFMajor facility superfamily sugar transporter protein regulates mating, pathogenicity, and sugar transport/absorption.
Microbiol Spectr
December 2024
College of Agriculture, South China Agricultural University, Guangzhou, China.
Sugarcane smut caused by is a global sugarcane disease, and studying its molecular pathogenesis is crucial for discovering new prevention and control targets. This study was based on the transcriptome sequencing data of two isolates with different pathogenicities ( and ) of the and screened out a gene encoding the Major Facility Superfamily (MFS) sugar transporter protein and named it . Knockout mutants ( and ) and complementary mutants ( and ) were obtained through polyethylene glycol (PEG)-mediated protoplast transformation technology.
View Article and Find Full Text PDFThe Cardiomyocyte in Cirrhosis: Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy.
Rev Cardiovasc Med
December 2024
Liver Unit, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Cirrhotic cardiomyopathy is defined as systolic and diastolic dysfunction in patients with cirrhosis, in the absence of any primary heart disease. These changes are mainly due to the malfunction or abnormalities of cardiomyocytes. Similar to non-cirrhotic heart failure, cardiomyocytes in cirrhotic cardiomyopathy demonstrate a variety of abnormalities: from the cell membrane to the cytosol and nucleus.
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