Nonmelanotic skin cancer is the most common human neoplasia and its incidence is rising. The completeness of resection is the most important quality feature of surgical treatment of nonmelanotic skin cancer, as a complete resection distinctly reduces local recurrence. In this trial, we analyze the incomplete resection rate of nonmelanotic skin cancer (N = 524) through plastic surgery assistant doctors in the first 3 years of surgical training. We find that the incomplete resection rate of nonmelanotic skin cancer decreases significantly (P = 0.026) from mean 12.1% in the first year of training to mean 5.7% in the third year of training, despite a gain in difficulty level concerning tumor localization. Moreover, we identify the following tumor features as a risk factor for incomplete resection: facial tumors (P = 0.034), recurrent lesions (P = 0.032), and the tumor class of the superficial basal cell carcinoma (P = 0.010). We prove that complete excision of nonmelanotic skin cancer distinctly depends on the surgeon's experience level.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/SAP.0b013e3182223d7b | DOI Listing |
JACC CardioOncol
June 2024
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Background: Relationships between the social determinants of health (SDOH) and cardiovascular health (CVH) of cancer survivors are underexplored.
Objectives: This study sought to investigate associations between the SDOH and CVH of adult cancer survivors.
Methods: Data from the U.
Eplasty
February 2024
London Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada.
Background: Nonmelanotic skin cancer (NMSC) refers to cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma. There have been many factors linked with the development of cSCC; however, ultraviolet radiation is the most notable culprit. Mutations in signaling genes, the gene, and genes encoding components of the NOTCH signaling pathways increase the risk of developing cSCC.
View Article and Find Full Text PDFTransplant Proc
November 2023
Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Nephrology Department, Tel Aviv Medical Center, Tel Aviv, Israel; Organ Transplantation Unit, Tel-Aviv Medical Center, Tel Aviv, Israel. Electronic address:
Background: With the aging of the population, more older patients are being considered for kidney transplantation; therefore, it is crucial to evaluate the risks and benefits of transplantation in this population. This study aimed to assess long-term outcomes of kidney transplantation in a cohort of patients who underwent kidney transplantation at age >70 years, compared with patients aged 60 to 69 years at transplantation.
Methods: Included in the study were 261 consecutive kidney transplant recipients: 52 were aged >70 years, and 209 were aged 60 to 69 years at transplantation.
Endocr Rev
November 2023
Department of Physiology, Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Recent research has unveiled an expansive role of NAD+ in cellular energy generation, redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health span and aging. This review provides a critical appraisal of the clinical pharmacology and the preclinical and clinical evidence for therapeutic effects of NAD+ precursors for age-related conditions, with a particular focus on cardiometabolic disorders, and discusses gaps in current knowledge. NAD+ levels decrease throughout life; age-related decline in NAD+ bioavailability has been postulated to be a contributor to many age-related diseases.
View Article and Find Full Text PDFRom J Morphol Embryol
May 2023
Department of Histology, Department of Neurology, University of Medicine and Pharmacy of Craiova, Romania;
Skin cancer is one of the most common types of cancer, with an increasing worldwide incidence in recent decades. The main risk factor for increasing the skin cancer incidence is ultraviolet (UV) radiation. Of the two major forms of skin cancer (melanomas and non-melanotic cancers), the cutaneous melanoma (CM) is the most aggressive form, causing about 80% of the deaths resulted from this type of tumor.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!