A new nanocomposite architecture is reported which combines prolate spheroidal hematite nanoparticles with drug-carrying layered double hydroxide [LDH] disks in a single structure. Spindle-shaped hematite nanoparticles with average length of 225 nm and width of 75 nm were obtained by thermal decomposition of hydrothermally synthesized hematite. The particles were first coated with Mg-Al-NO3-LDH shell and then subjected to anion exchange with salicylate ions. The resulting bio-nanohybrid displayed a close structural resemblance to that of the Ring Nebula. Scanning electron microscope and transmission electron microscopy images showed that the LDH disks are stacked around the equatorial part of the ellipsoid extending along the main axis. This geometry possesses great structural tunability as the composition of the LDH and the nature of the interlayer region can be tailored and lead to novel applications in areas ranging from functional materials to medicine by encapsulating various guest molecules.
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http://dx.doi.org/10.1186/1556-276X-6-116 | DOI Listing |
J Chem Phys
January 2025
Out of Equilibrium Group, Department of Physics, Indian Institute of Technology Delhi, New Delhi 110016, India.
In biological systems such as cells, the macromolecules, which are anisotropic particles, diffuse in a crowded medium. In the present work, we have studied the diffusion of spheroidal particles diffusing between cylindrical obstacles by varying the density of the obstacles as well as the spheroidal particles. Analytical calculation of the free energy showed that the orientational vector of a single oblate particle will be aligned perpendicular, and a prolate particle will be aligned parallel to the symmetry axis of the cylindrical obstacles in equilibrium.
View Article and Find Full Text PDFAdv Mater
December 2024
Department of Materials Science, Institute of Pure and Applied Sciences, and Tsukuba Research Center for Energy Materials Science (TREMS), University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan.
Conventional laser panel displays are developed through the mass integration of electrically pumped lasers or through the incorporation of a beam steering system with an array of optically pumped lasers. Here a novel configuration of a laser panel display consisting of a non-steered pumping beam and an array of electrically Q-switchable lasers is reported. The laser oscillator consists of a robust, self-standing, and deformable minute droplet that emits laser through Whispering-Gallery Mode resonance when optically pumped.
View Article and Find Full Text PDFMicrosc Res Tech
December 2024
Faculty of Science, Department of Biology, Kastamonu University, Kastamonu, Türkiye.
In this study, the morphological properties of pollen of 14 species from 9 different sections of the genus Astragalus L. (Fabaceae) distributed in Türkiye were examined, identified, and compared under light microscope (LM) and scanning electron microscope (SEM). Pollen grains of the studied taxa are radially symmetrical and isopolar.
View Article and Find Full Text PDFGastro Hep Adv
August 2024
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan.
Background And Aims: Drug-induced liver injury (DILI) is a major failure mode in pharmaceutical development. This study aims to address the limitations of existing preclinical models by assessing a high-throughput, microfluidic liver-on-a-chip system, termed "Curio Barrier Liver Chips," and its capacity to recapitulate the effects of chronic hepatotoxic drug treatment through metabolic and phenotypic characterization.
Methods: Curio Barrier liver chips (Curiochips), fabricated in an 8 × 2 well configuration, were utilized to establish three dimensional liver organoid cultures.
J Mater Chem B
December 2024
Department of Materials & Henry Royce Institute, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, UK.
Supramolecular bioinspired self-assembling peptide hydrogel (SAPH) scaffolds represent a class of fully defined synthetic materials whose chemical and mechanical properties can be finely engineered. In this study, the relationship between SAPHs physicochemical properties and HepG2 cells viability, spheroid formation and function are discussed. We first report that negatively charged SAPHs promote hepatocyte proliferation and spheroids formation 3D culture while positively charged SAPHs lead to hepatocyte death irrespective of the hydrogel mechanical properties.
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