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Higher Processed Blood Volume of Granulocyte and Monocyte Adsorption Apheresis Ameliorates Long-Term Disease Activity in Ulcerative Colitis Patients.
J Clin Med Res
December 2024
Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.
Background: Granulocyte and monocyte adsorption apheresis (GMA) is a therapeutic option for remission induction in the active ulcerative colitis (UC) patients. Effects of high processed blood volume of GMA as remission induction therapy on the long-term prognosis of UC patients have remained unclear. For this study, we investigated the relation between re-exacerbation of UC and the processed blood volume of GMA performed as induction therapy.
View Article and Find Full Text PDFBiopsy-Proven T-Cell Mediated Rejection After Belatacept Rescue Conversion: A Multicenter Retrospective Study.
Transpl Int
December 2024
Department of Nephrology, Kidney Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
After kidney transplantation, conversion to belatacept is a promising alternative in patients with poor graft function or intolerance to calcineurin inhibitors. The risk of acute rejection has not been well described under these conditions. Here we present a retrospective multicenter study investigating the occurrence of acute rejection after conversion in 901 patients (2011-2021).
View Article and Find Full Text PDFInduction of Plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy.
Am J Physiol Renal Physiol
December 2024
Division of Nephrology, Department of Medicine, Stony Brook University, , Stony Brook, NY.
Glomerular endothelial cell (GEnC) injury is a common feature across the wide spectrum of glomerular diseases. We recently reported that the endothelial-specific knockout of increases the susceptibility to GEnC injury and subsequent development of subacute thrombotic microangiopathy (TMA). However, the mechanism(s) mediating GEnCs response to injury in TMA are poorly understood.
View Article and Find Full Text PDFGranulomatosis with polyangiitis with rapidly progressive glomerulonephritis treated with a multipronged approach-a case based review.
CEN Case Rep
December 2024
Division of Rheumatology, University of Missouri, Kansas City, MO, 64108, USA.
Article Synopsis
- Granulomatosis with polyangiitis is a type of vasculitis affecting small to medium-sized blood vessels, with kidney involvement impacting prognosis.
- Treatment for severe cases often involves a combination of corticosteroids and medications like rituximab or cyclophosphamide, but there's no clear consensus on the best regimen.
- The case discussed highlights the effectiveness of using lower-dose cyclophosphamide alongside rituximab for patients with treatment-resistant forms of the disease and emphasizes better tolerance at lower doses.
Diffuse large B-cell lymphoma with rapid kidney enlargement after induction of hemodialysis in a patient with IgG4-related disease.
CEN Case Rep
December 2024
Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
A 76-year-old Japanese man was incidentally diagnosed with a pancreatic head tumor on computed tomography after surgery for colon cancer. He underwent pancreatoduodenectomy and was diagnosed with IgG4-related autoimmune pancreatitis. Concurrent chronic kidney disease gradually progressed and chronic hemodialysis was introduced 2 years later.
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