AI Article Synopsis
- The study analyzed the DNA content of tongue squamous cell carcinoma (TSCC) in two age groups: 37 young patients under 40 and 28 older patients over 50, to see how DNA ploidy relates to their clinical data.
- Among young patients, there was a significantly higher percentage of non-smokers and non-drinkers, while DNA abnormalities like aneuploidy were found more frequently in the younger group compared to older patients.
- The findings suggest that TSCC in young patients is unique, with a higher level of genomic instability and genetic differences compared to older patients.
Article Abstract
Aims: This multi-centre analysis assessed the DNA content of TSCC in 37 young patients (<40 years) and 28 old patients (>50 years) and determined the correlation of DNA ploidy findings with clinicopathological data.
Methods And Results: Image cytometry was carried out using an automated cellular imaging system on Feulgen-stained histological sections to obtain high-fidelity DNA histograms. Among young patients, 37.8% were females compared to 18.7% in the older group (P=0.002). In total, 48.6% patients were non-smokers and 40.5% were non-drinkers compared to 10.7% non-smokers and non-drinkers in the older group (P<0.0001). TNM, clinical stage of disease and histological grade of differentiation did not differ between groups. Tumour aneuploidy was detected in 86.5% and tetraploidy in 24.3% young patients; this was significantly greater than in the older group where 64.3% were aneuploid (P<0.0001) and 7.2% tetraploid (P<0.0001). The mean values of DNA index (DI) and DNA heterogeneity index as well as the percentage of cells with DI exceeding 5N were higher in young patients (P<0.0001).
Conclusions: Young patients with TSCC represent a distinct clinical entity. The high incidence of DNA ploidy abnormalities suggest that they may have increased genomic instability and indicates underlying genetic differences between TSCC in young and older patients.
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| http://dx.doi.org/10.1111/j.1365-2559.2011.03863.x | DOI Listing |
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