AI Article Synopsis
- The study investigates how intracellular second messengers influence the expression of Ia antigens induced by IFN-gamma in astroglia and microglia.
- Reagents that increase cAMP or activate PKC lower Ia antigen expression in astroglia, while cAMP does not affect microglia's Ia expression.
- These results suggest that cAMP and PKC have a negative regulatory role in astroglia but not in microglia, which could help explain why Ia+ microglia are often found in neurodegenerative diseases but not astroglia.
Article Abstract
The roles of intracellular second messengers in interferon-gamma (IFN-gamma)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-gamma. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-gamma-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-gamma-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119474 | PMC |
| http://dx.doi.org/10.1016/0165-5728(90)90164-i | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!