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Single Center-Based Real-World Experience on Anti-IL 1 Biological Response Modifiers: A Case Series and Literature Review.
Children (Basel)
September 2024
Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Article Synopsis
- Anti-IL-1 biologics, particularly anakinra, are being explored for treating autoimmune and autoinflammatory conditions in children, highlighting their off-label use.
- Anakinra has shown effectiveness in personalized treatment approaches and for conditions like rheumatic fever and post-viral arthritis, while canakinumab has been linked to long-term remission.
- The authors call for increased collaboration to enhance access to these medications, aiming to better manage harmful inflammation in pediatric patients.
Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever.
J Clin Rheumatol
October 2024
Division of Pediatric Rheumatology and Nephrology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey.
Article Synopsis
- Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease treated mainly with colchicine, but 5%-10% of patients don't respond adequately and may need anti-IL-1 treatments.
- This study examined factors related to the withdrawal of anti-IL-1 agents in patients who were resistant to colchicine, comparing their demographic and clinical characteristics over a ten-year period.
- Results showed that lower severity scores and the absence of exertional leg pain or comorbidities are linked to the successful discontinuation of anti-IL-1 treatments in colchicine-resistant FMF patients.
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction.
Inflammopharmacology
August 2024
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the mortality rate of myocardial infarction (MI) has improved dramatically in recent years due to timely treatment, adverse remodeling of the left ventricle continues to affect cardiac function. Various immune cells are involved in this process to induce inflammation and amplification.
View Article and Find Full Text PDFFamilial Mediterranean Fever-Associated Retinal Vasculitis: A Rare Manifestation Successfully Managed with IL-1 Pathway Inhibitors.
Ocul Immunol Inflamm
November 2024
Department of Ophthalmology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Purpose: To investigate the rare manifestation of retinal vasculitis in Familial Mediterranean fever (FMF) and its correlation with specific gene mutations, particularly the MEFV gene, with a focus on the severity of phenotypes and systemic vasculitis.
Methods: A case report of a 45-year-old Armenian patient with FMF history and dual mutations (M680I and M694V) was analyzed. Clinical assessments, including ocular examinations, were conducted at various stages of the disease.
Case report: Successful treatment with canakinumab of a patient with active ileitis associated with familial Mediterranean fever.
Int J Rheum Dis
January 2024
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
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