The potential of oral exposure to calcium and magnesium citrate, a natural product obtained from dolomite, to initiate teratogenesis was analyzed in Wistar rats. Animals received calcium and magnesium citrate oral doses of 250, 500 and 1000 mg/kg during the period of gestation from day 6 to 17 post conception. Maternal, embryo and fetal toxicity was evaluated. Calcium and magnesium citrate exposure did not produce maternal toxicity assessed by clinical observations, body weight gain, food intake, hematology, biochemical parameters and necropsy finding. Signs of embryo-fetal toxicity were not observed. Skeletal and visceral malformations were seen occasionally in all drug-treated and control groups. Skeletal and visceral variations were similar in control and drug-treated groups except for incomplete ossification rib. These finding was spontaneous and unrelated to the drug. In conclusion, in this study we found that the oral exposure to rats of up to 1000 mg/kg of calcium and magnesium citrate during organogenesis did not induce significant maternal and embryo-fetal toxicity. The experimentally derived NOAEL for developmental toxicity was 1000 mg/kg.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.etp.2011.05.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioabsorbable magnesium-based bulk metallic glass composite (BMGC) for improved medial opening wedge high tibial osteotomy in knee osteoarthritis.
J Orthop Translat
January 2025
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 6F Biomedical Technology Building, No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City, 23564, Taiwan.
Background And Objective: Osteoarthritis is a widespread and debilitating condition, particularly affecting the medial compartment of knee joint due to varus knee deformities. Medial opening wedge high tibial osteotomy (MOWHTO) has emerged as an effective treatment, but it comes with challenges like fractures, correction loss, and nonunion, leading to unsatisfactory results in up to 26 % of patients. In response, our study explores the potential of a bioabsorbable magnesium-based bulk metallic glass composite (MgZnCa BMGC) enriched with molybdenum particles as an innovative solution for MOWHTO.
View Article and Find Full Text PDFSpatial-Temporal Variation of Grain Magnesium, Calcium and Their Response to Phosphorus Nutrition in Sweet Corn.
Food Sci Nutr
January 2025
International Magnesium Institute, College of Resources and Environment Fujian Agriculture and Forestry University Fuzhou China.
Sweet corn ( L. ) is gaining global popularity as a staple crop and a vegetable due to its high nutritional value. However, information on grain magnesium (Mg) and calcium (Ca) status and their response to phosphorus (P) fertilization in sweet corn is still insufficient.
View Article and Find Full Text PDFStudies on the nutritional strength of various hyacinth bean varieties for their potential utilization as promising legume.
J Food Sci Technol
January 2025
Grain Science and Technology Division, Defence Food Research Laboratory, Mysore, Karnataka 570011 India.
This study aimed to compare thirteen different varieties of hyacinth beans analyzedfor their nutritional and antinutritional constituents. The study classified HA-3, HA-4, and Kadale Avare as Lignosus varieties, while the remaining varieties Arka, Pusa, CO, and NS, were classified as Typicus. The protein content ranged from 19.
View Article and Find Full Text PDFDeamination mechanism of modified magnesium slag using wet aging and its performance evolution as backfill material.
J Environ Manage
January 2025
School of Business, Xi'an University of Finance and Economics, Xi'an, 710100, China.
The purpose of this study is to solve the problem of ammonia (NH) release when modified magnesium slag (MMS) is used as coal mine backfill cementitious material, and to explore its chemical mechanism and put forward effective solutions. Uniaxial compressive strengths (UCS) hydration kinetics, scanning electron microscope (SEM), and thermogravimetric analysis-derivative thermogravimetry (TG-DTG), X-ray diffractometer (XRD) and other testing methods were used to study the evolution of the properties of MMS-based backfill material, which provided a scientific basis for the safe utilization of MMS. First, the chemical mechanism underlying the release of NH from MMS was identified, and it was confirmed that MgN and LiN are the main nitrogen sources.
View Article and Find Full Text PDFAssessment of geochemistry and irrigation suitability of the River Ganga, Varanasi, India: PCA reduction for water quality index and health risk evaluation.
Environ Sci Pollut Res Int
January 2025
Institute of Environment and Sustainable Development, Banaras Hindu University, Varanasi, 221005, India.
Surface water chemistry of the River Ganga at Varanasi was analyzed at 10 locations over 3 years (2019-2021) across pre-monsoon, monsoon, and post-monsoon seasons. The study aimed to assess water parameters using principal component analysis (PCA), calculate the water quality index (WQI), determine processes governing water chemistry, evaluate irrigation suitability, and estimate non-carcinogenic health risks. The physical parameters measured included pH (8.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!