Background: Since oxidative stress has been implicated in a neurodegenerative disease such as Alzheimer's disease (AD), natural antioxidants are promising candidates of chemopreventive agents. This study examines antioxidant and neuronal cell protective effects of various fractions of the methanolic extract of Erigeron annuus leaf and identifies active compounds of the extract.
Methods: Antioxidant activities of the fractions from Erigeron annuus leaf were examined with [2,2-azino-bis(3-ethylbenz thiazoline-6-sulfonic acid diammonium salt)] (ABTS) and ferric reducing antioxidant power (FRAP) assays. Neuroprotective effect of caffeic acid under oxidative stress induced by H2O2 was investigated with [3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (MTT) and lactate dehydrogenase (LDH) assays.
Results: This study demonstrated that butanol fraction had the highest antioxidant activity among all solvent fractions from methanolic extract E. annuus leaf. Butanol fraction had the highest total phenolic contents (396.49 mg of GAE/g). Caffeic acid, an isolated active compound from butanol fraction, showed dose-dependent in vitro antioxidant activity. Moreover, neuronal cell protection against oxidative stress induced cytotoxicity was also demonstrated.
Conclusion: Erigeron annuus leaf extracts containing caffeic acid as an active compound have antioxidative and neuroprotective effects on neuronal cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145603 | PMC |
| http://dx.doi.org/10.1186/1749-8546-6-25 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ecophysiological and Molecular Analysis of Contrasting Genotypes for Leaf Senescence in Sunflower ( L.) Under Differential Doses of N in Soil.
Plants (Basel)
December 2024
Instituto de Biotecnología, UEDD INTA CONICET, Buenos Aires 1686, Argentina.
Leaf senescence in plants is the last stage of leaf development and is characterized by a decline in photosynthetic activity, an active degeneration of cellular structures, and the recycling of accumulated nutrients to areas of active growth, such as buds, young leaves, flowers, fruits, and seeds. This process holds economic significance as it can impact yield, influencing the plant's ability to maintain an active photosynthetic system during prolonged periods, especially during the grain filling stage, which affects plant weight and oil content. It can be associated with different stresses or environmental conditions, manifesting itself widely in the context of climate change and limiting yield, especially in crops of agronomic relevance.
View Article and Find Full Text PDFMycovirome of Diaporthe helianthi and D. gulyae, causal agents of Phomopsis stem canker of sunflower (Helianthus annuus L.).
Virus Res
January 2025
USDA-ARS, Application Technology Research Unit, Wooster, OH, United States. Electronic address:
Diaporthe gulyae and D. helianthi cause Phomopsis stem canker, which is a yield-limiting fungal disease of sunflower (Helianthus annuus L.) in the United States.
View Article and Find Full Text PDFComparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower.
PLoS One
December 2024
Liaoning Academy of Agricultural Sciences, Shenyang, China.
Sclerotinia sclerotiorum as a necrotrophic fungus causes the devastating diseases in many important oilseed crops worldwide. The preferred strategy for controlling S. sclerotiorum is to develop resistant varieties, but the molecular mechanisms underlying S.
View Article and Find Full Text PDFFirst report of causing Phomopsis stem canker on sunflower ( L.) in Minnesota.
Plant Dis
December 2024
USDA-ARS Plains Area, Edward T. Schafer Agricultural Research Center, Sunflower Improvement Research Unit, Fargo, North Dakota, United States;
Cultivated sunflower (Helianthus annuus L.) is a globally important oilseed crop that is grown primarily in the Northern Great Plains region of the United States. In September 2018, sunflower stems exhibiting brown stem lesions centered on the leaf axils and accompanied by pith degradation, consistent with symptoms of Phomopsis stem canker (PSC) disease, were sampled from a commercial field of approximately 520 hectares in Polk County, MN (47°50'24" N, 96.
View Article and Find Full Text PDFPan-genome wide identification and analysis of the gene family in sunflowers ( L.) revealed their intraspecies diversity and potential roles in abiotic stress tolerance.
Front Plant Sci
November 2024
Department of Agronomy, Hetao College, Bayannur, China.
Introduction: S-adenosylmethionine (SAM), a key molecule in plant biology, plays an essential role in stress response and growth regulation. Despite its importance, the SAM synthetase gene family in sunflowers remains poorly understood.
Methods: In this study, the genes were identified from the sunflower genome.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!