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Novel research model for in vitro immunotherapy: co-culturing tumor organoids with peripheral blood mononuclear cells.
Cancer Cell Int
December 2024
Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Tumor organoids have emerged as powerful tools for in vitro cancer research due to their ability to retain the structural and genetic characteristics of tumors. Nevertheless, the absence of a complete tumor microenvironment (TME) limits the broader application of organoid models in immunological studies. Given the critical role of immune cells in tumor initiation and progression, the co-culture model of organoids and peripheral blood mononuclear cells (PBMCs) may provide an effective platform for simulating the interactions between immune and tumor cells in vitro.
View Article and Find Full Text PDFMiddle ear secretions following spontaneous CSF leak repair may represent effusion rather than CSF leak.
Eur Arch Otorhinolaryngol
December 2024
Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel.
Objective: To characterize middle ear (ME) effusion still present 2 months after repair surgery for spontaneous cerebrospinal fluid (CSF) leak via the temporal bone (TB).
Study Design: A retrospective chart review (2011-2022).
Setting: Tertiary referral academic center.
Supplemental Intervention for Alcohol Use Disorder Treatment Patients With a Co-Occurring Anxiety Disorder: Technical Development and Functional Testing of an Autonomous Digital Program.
JMIR Form Res
December 2024
Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Background: Anxiety disorders are common in alcohol use disorder (AUD) treatment patients. Such co-occurring conditions ("comorbidity") have negative prognostic implications for AUD treatment outcomes, yet they commonly go unaddressed in standard AUD care. Over a decade ago, we developed and validated a cognitive behavioral therapy intervention to supplement standard AUD care that, when delivered by trained therapists, improves outcomes in comorbid patients.
View Article and Find Full Text PDFHumans have a long-standing relationship with the natural world, particularly in how they engage with plants-referred to as people-plant relationships. While plants naturally live outdoors, people have been including them inside built environments for centuries. Although the benefits of indoor plants are well documented in research, there is limited exploration of individuals' subjective relationships with their indoor plants.
View Article and Find Full Text PDFBur., a versatile plant with medicinal, edible, landscaping, and ecological applications, holds significant economic value and boasts a long-standing history of utilization in China. Despite its robust adaptability, rapid growth, and extensive distribution, the current research gap concerning the physiological mechanisms underlying stem cutting propagation hampers the development of efficient strategies for commercial-scale propagation of , particularly for large-scale cultivation.
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