Leishmaniasis is a disease complex caused by the parasite of genus Leishmania. Visceral Leishmaniasis is caused by Leishmania donovani transmitted to human by sand fly. Some wild animals and human reservoir is the major reservoir in most of the cases. The disease is prevalent in different parts of the world including India, Nepal, Bangladesh, Sudan and Brazil. It has also been reported from Northern half of Pakistan. In Hazara Division, it has been reported from Galiat, Battagram, Kaladhaka, Kohistan, Balakot, Kaghan and adjoining areas of Azad Jammu & Kashmir. A focus of visceral Leishmaniasis was detected in villages located about 15 Km from Abbottabad city in year 2000. Sporadic cases were reported from the suburbs of Abbottabad but not from Abbottabad city. All these cases and cases from the other parts of Pakistan were children <12 years of age and the disease was not seen in adults except only one child, 11 year old. We report the 1st case from this area which is 16 years old girl.
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PLoS Negl Trop Dis
December 2024
Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia.
Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae.
View Article and Find Full Text PDFIn Silico Pharmacol
December 2024
Laboratory of Cell and Molecular Biology, Department of Botany, Centre of Advanced Study, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, 700019 India.
Visceral Leishmaniasis, caused by is the second most deadly parasitic disease, causing over 65,000 deaths annually. Synthetic drugs available in the market, to combat this disease, have numerous side effects. In this backdrop, we aim to find safer antileishmanial alternatives with minimal side effects from mushrooms, which harbour various secondary metabolites with promising efficacy.
View Article and Find Full Text PDFAnal Bioanal Chem
December 2024
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, 51006, Tartu, Estonia.
The analysis of the volatile compounds released by biological samples represents a promising approach for the non-invasive diagnosis of a disease. The present study, focused on a population of dogs infected with canine leishmaniasis, aimed to decipher the volatolomic profile associated with this disease in dogs, which represent the main animal reservoir for Leishmania pathogen transmission to humans. The volatiles emitted by the breath and hair of dogs were analysed employing the gas chromatography-mass spectrometry (GC-MS) technique.
View Article and Find Full Text PDF3 Biotech
January 2025
Cell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University, Campus Almora, Almora, Uttarakhand India.
Unlabelled: Visceral leishmaniasis (VL), caused by , remains challenging to treat due to severe side effects and increasing drug resistance associated with current chemotherapies. Our study investigates the anti-leishmanial potential of from Uttarakhand, India, with extracts prepared from leaves and stems using ethanol and hexane. Advanced GC-MS analysis identified over 100 bioactive compounds, which were screened using molecular docking to assess their binding to LdHEL-67, a DDX3-DEAD box RNA helicase of donovani.
View Article and Find Full Text PDFActa Trop
December 2024
Department of Parasitology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Basic Oncology, Institute of Health Sciences, Ege University, Izmir, Turkey; Translational Pulmonary Research Center (EGESAM), Ege University, Izmir, Turkey. Electronic address:
Leishmaniasis is a neglected infectious disease that affects millions of people worldwide. Visceral leishmaniasis (VL) caused by Leishmania infantum and cutaneous leishmaniasis (CL) caused by L. major/ L.
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