Objective: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
Methods: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
Results: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
Conclusion: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299963 | PMC |
| http://dx.doi.org/10.1007/s00420-011-0673-0 | DOI Listing |
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