AI Article Synopsis
- The adaptability of the BODIPY scaffold for solid-phase chemistry has been debated, limiting its diversification.
- This research presents the first successful solid-phase synthesis of a high-purity BODIPY library.
- The library was tested on various proteins, leading to the discovery of a fluorescent sensor (Ig Orange), with binding confirmed through SPR experiments.
Article Abstract
The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.
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| http://dx.doi.org/10.1039/c1cc11774b | DOI Listing |
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