AI Article Synopsis
- A new series of amphiphilic α-cyclodextrins was created by attaching N-acylated amino acids to their primary hydroxyl groups through ester bonds.
- The synthesis involved a specific process of hexa-brominating the hydroxyls and then substituting them with N-acetyl residues using DBU.
- The resulting compounds demonstrated significant capabilities in extracting dopamine from water, and their binding affinity to dopamine was analyzed using molecular docking techniques.
Article Abstract
A new series of amphiphilic α-cyclodextrins were synthesized by grafting N-acylated amino acids [valine, leucine, phenylalanine, methionine, and tryptophan (3a-e)] to the primary hydroxyl groups via ester bond formation. The synthetic pathway involves selective hexa-bromination of the primary hydroxyls followed by per-substitution with the carboxylate moiety of the N-acetyl residues in the presence of DBU (1,8-diazabicyclo[5,4,0]undec-7-ene). The ability of the synthetic compounds for the extraction of dopamine was studied. The results showed a considerable ability of some of the amphiphilic compounds for the extraction of dopamine into octanol phase from water. To complete the study, the binding affinity of dopamine toward the synthetic host molecules was calculated by using of the molecular docking technique.
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| http://dx.doi.org/10.1016/j.bmc.2011.05.048 | DOI Listing |
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