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Characteristics of a revised quick sequential organ failure assessment score (RqSOFA) to predict in-hospital mortality of patients visiting the emergency department via ambulance: an observational cohort study.
Intern Emerg Med
December 2024
The Pediatric Research in Emergency Therapeutics (PRETx) Program, Division of Emergency Medicine, Department of Pediatrics, University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, BC, Canada.
The National Early Warning Score (NEWS), Quick Sequential Organ Failure Assessment (qSOFA), and modified qSOFA (MqSOFA) are scoring systems that rely on vital signs. However, NEWS is time-consuming, qSOFA has low sensitivity, and MqSOFA includes a difficult calculation. To address these issues, we developed the Revised qSOFA score (RqSOFA) that consists of percutaneous oxygen saturation, oxygen usage, Simple Shock Index, and the parameters of qSOFA.
View Article and Find Full Text PDFFrom Poppers to Peril: Recreational Nitrite-Induced Methemoglobinemia.
Cureus
August 2024
Critical Care Medicine, Ascension Providence Hospital, Southfield, USA.
Article Synopsis
- * A 43-year-old man with a history of diabetes and hypertension showed symptoms of methemoglobinemia, including bluish discoloration of his fingers, after using the inhalant "Rush," leading to low oxygen saturation and elevated methemoglobin levels.
- * Treatment with methylene blue successfully resolved the patient’s symptoms, but resulted in green urine, highlighting the importance of thorough history taking and awareness of treatment side effects in managing inhalant-related cases.
Development of a Clinical Score for Predicting 28-Day Mortality in Geriatric Sepsis Patients; a Cohort study.
Arch Acad Emerg Med
June 2024
Department of Emergency Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Introduction: Sepsis is a significant and common cause of death and burden among critically ill patients, which has increasing incidence and mortality in adults over 60 and advanced age. This study aimed to develop an easy-to-use clinical tool for assessing 28-day mortality risk in older sepsis patients upon their initial assessment in the emergency department (ED).
Method: A retrospective cohort study was conducted using electronic medical records of older (≥60 years) ED patients with suspected sepsis from August 1, 2018, to December 31, 2018.
Quick and effective approximation of in silico saturation mutagenesis experiments with first-order taylor expansion.
iScience
September 2024
Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA.
To understand the decision process of genomic sequence-to-function models, explainable AI algorithms determine the importance of each nucleotide in a given input sequence to the model's predictions and enable discovery of regulatory motifs for gene regulation. The most commonly applied method is saturation mutagenesis (ISM) because its per-nucleotide importance scores can be intuitively understood as the computational counterpart to saturation mutagenesis experiments. While ISM is highly interpretable, it is computationally challenging to perform for many sequences, and becomes prohibitive as the length of the input sequences and size of the model grows.
View Article and Find Full Text PDFAnaesthesia Management in a Case of Ludwig's Angina With Difficult Airway Managed by Emergency Tracheostomy.
Cureus
August 2024
Anaesthesiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Severe neck infections present significant challenges for anesthesiologists due to the complexities associated with managing difficult airways. Ludwig's angina, a rapidly progressing infection of the submandibular space, exemplifies these challenges due to the high risk of airway obstruction. This case report details an emergency procedure performed to drain Ludwig's angina, highlighting the difficulties encountered and the strategies employed.
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