AI Article Synopsis
- The study investigates the hepatoprotective effects of Melatonin and Tinospora cordifolia on posthepatic cholestasis induced by bile duct ligation in rats.
- Both compounds were administered orally to compare their effects with previous studies that used injectable Melatonin.
- Microscopy, lab tests, and oxidative stress measurements show that both substances significantly protect the liver and may reduce oxidative stress caused by cholestasis in humans.
Article Abstract
Posthepatic cholestasis is figured by the onset of an intense oxidative stress, followed by important cellular morphological and functional abnormalities. The aim of this experimental study is to assess the hepatoprotective effects of Melatonin and extract of Tinospora cordifolia in bile duct ligation induced jaundice in rats. We choosed to administrate both pharmacological products per os, in order to compare the results with those already published, in which melatonin was administrated injectable. The assessment of microscopy, lab tests and the measurement of oxidative stress products indicates a marked hepatoprotective effect of those two compounds. The results allowed us to recomand the use of melatonin and Tinospora cordifolia to reduce the cholestasis's oxidative stress in human.
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