A total of 138 middle and aged cynomolgus monkeys (Macaca fascicularis) (above 10 years) were classified into three groups based on fasting plasma glucose (FPG) values, specifically low FPG, normal FPG, and high FPG group. Total cholesterol (TCHO), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected in blood by automatic biochemical analyzer. The mRNA expressions of 37 diabetes-associated genes were analyzed with Real-time PCR in monocytes isolated from monkey peripheral blood. No significant correlation between the four serum lipid indictors HDL-C, LDL-C, TCHO, TG and FPG (P>0.05) were found. However, the expressions of ACE, ACLY, PRKCB1, SLC2A4, SNAP23, VAPA, IGF2BP2, and IFNG were significantly enhanced when FPG increased (P<0.05).
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| http://dx.doi.org/10.3724/SP.J.1141.2011.03300 | DOI Listing |
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Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.
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Department of Hebei Provincial Key Laboratory of Basic Medicine for Diabetes, The Shijiazhuang Second Hospital, Shijiazhuang, China.
Objectives: To explore the effect and the probable mechanisms of JLD in the treatment of type 2 diabetes mellitus (T2DM) - associated cognitive impairment (TDACI).
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Protective effects of berberine against diabetes-associated cognitive decline in mice.
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Department of Biochemistry , King George's Medical University, Lucknow, Uttar Pradesh, India.
Aims: Diabetes associated cognitive decline (DACD) is a common CNS-related consequence of diabetes. The primary clinical manifestation of DACD includes learning and memory impairment. Unfortunately, there is no cure to delay the cognitive symptoms of diabetes.
View Article and Find Full Text PDFFrom Diabetes to Dementia: Identifying Key Genes in the Progression of Cognitive Impairment.
Brain Sci
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School of Nursing, Peking University, Beijing 100191, China.
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Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes.
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Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany. Electronic address:
Introduction: Fetal development is dependent on placenta and affected by multiple factors including maternal diabetes. Here we aimed to identify maternal diabetes-associated changes in placentas and analyzed placental gene expression to understand its modulation by maternal diabetes and birth mode.
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miR-210 as a therapeutic target in diabetes-associated endothelial dysfunction.
Br J Pharmacol
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Division of Cardiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- This study investigates the role of microRNA (miR)-210 in endothelial cells and its potential therapeutic effects on diabetes-related endothelial dysfunction.* -
- Using various mouse models and human endothelial cells, researchers discovered that lower levels of miR-210 in diabetic conditions impair endothelium-dependent relaxation (EDR), but restoring its levels helps improve vascular function.* -
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