Subjective musculoskeletal symptoms are more frequently complained about in cold store work and in related conditions than those experienced in normal temperature work. This cross sectional study was undertaken to evaluate the effects of indoor cooling and cold storage goods on the prevalence of subjective symptoms in summer. Female workers sorting cold storage goods (exposed group) were the main subjects of this study (n=47). We also included a group of female workers engaged sorting dry goods as the unexposed to cold group (n=86). Work load for the two groups were estimated according to the recommended criteria. A self-administered questionnaire covering age, occupational career, smoking, alcohol drinking and physical exercise, present or past history of diseases, individual protective measures against cold or heat, and subjective symptoms (60 items) was used. The air temperature of the site at the start of working time for the workers sorting cold storage goods was 22.2℃ which was significantly lower than those measured for the other two work places (25.4℃ and 25.4℃) of the unexposed to cold group. Environmental temperatures at the foot level at the sorting workshop of cold storage goods and dry goods were ca.16℃ and 26℃ all day, respectively. The surface temperatures of cold storage goods were between -2.8℃ and 9.4℃. The surface temperature of dry goods was 26.5℃. Among the working characteristic items, only daily working hours in the exposed group (5.6 ± 0.6 h) were significantly longer than those in the unexposed to cold group (4.6 ± 0.9 h) (p<0.01). The prevalence rates of finger cold sensation, stiffness in the fingers, pain in the wrist, pain in the elbow, back dullness, back pain, low-back cold sensation, foot cold sensation and pain in the foot in the exposed group were significantly higher than those in the unexposed to cold group (p<0.05 or p<0.01). Pain in the fingers, numbness in the fingers, pain in the foot and foot numbness due to the cold in the exposed group were significantly higher than those in the unexposed to cold group (p<0.05 or p<0.01). These results suggest that indoor cooling and/or job activities related to cold storage goods could, to some extent, affect peripheral circulatory disturbances; and it could be regarded as a factor related to musculoskeletal symptoms among the exposed workers.
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http://dx.doi.org/10.2486/indhealth.ms1201 | DOI Listing |
Front Endocrinol (Lausanne)
January 2025
Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Background: Thin endometrial thickness (EMT) and advanced age are both common risk factors for adverse neonatal outcomes (ANOs). However, studies evaluating the impact of EMT and combined effect of EMT and age on ANOs remain scarce with conflicts.
Method: A retrospective cohort study was conducted on 7,715 singleton deliveries from frozen embryo transfer (FET) cycles between 2017 and 2021.
Int J Pharm
January 2025
Department of Pharmaceutics, Institute of Pharmaceutical Sciences, University of Freiburg, Sonnenstr. 5, Freiburg i. Br. 79104 Germany; ten23 health AG, Mattenstr. 22, Basel 4058 Switzerland. Electronic address:
Lipid nanoparticles (LNPs) have demonstrated their therapeutic potential as safe and effective drug delivery systems for nucleic acids during the COVID-19 pandemic. However, one of the main challenges during technical CMC (Chemistry, Manufacturing, and Controls) development is their long-term stability at temperatures of 2-8 °C or higher, which may be improved by the removal of water by lyophilization. In this study, we identified lyo-/cryo-protectants for freeze-dried mRNA-LNP formulations beyond conventional excipients such as sucrose and trehalose as T-modifiers using polyA as a surrogate.
View Article and Find Full Text PDFJ Plant Physiol
January 2025
Department of Ecology, Faculty of Sciences, University of Málaga, Málaga, Spain.
Cold-temperate and Arctic hard bottom coastal ecosystems are dominated by kelp forests, which have a high biomass production and provide important ecosystem services, but are subject to change due to ocean warming. However, the photophysiological response to increasing temperature of ecologically relevant species, such as Laminaria digitata, might depend on the local thermal environment where the population has developed. Therefore, the effects of temperature on growth rate, biochemical composition, maximum quantum yield, photosynthetic quotient and carbon budget of young cultured sporophytes of Laminaria digitata from the Arctic at Spitsbergen (SPT; cultured at 4, 10 and 16 °C) and from the cold-temperate North Sea island of Helgoland (HLG; cultured at 10, 16 and 22 °C) were comparatively analyzed.
View Article and Find Full Text PDFCell Transplant
January 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Non-cryo and hypothermic preservations are two available options for short-term storage of living cells. For long-term cell storage, cryopreservation is an essential procedure as it prolongs the storage time, allowing for the transport and testing of cells, as well as the establishment of cell banks. But it is unclear whether cryopreservation reduces the therapeutic effects of human umbilical cord mesenchymal stem cells (hucMSCs) on osteoarthritis (OA).
View Article and Find Full Text PDFSyst Biol Reprod Med
December 2025
College of Medicine, Department of Basic Sciences, Roseman University of Health Sciences, Las Vegas, NV, USA.
Cryopreservation, the use of very low temperatures to preserve structurally intact living cells and tissues, has seen exponential growth in the field of fertilization (IVF). In the last decade, cryopreservation of embryos and freeze-all protocols have become an essential aspect and a prerequisite for a successful IVF outcome. Moreover, vitrification, which is a fast and safe cryopreservation method, has proved to be an effective choice for cryopreserving gametes and embryos.
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