We report the synthesis of a series of novel 2'-deoxy-2',2'-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2'-deoxy-2',2'-difluoro-5-iodo- and -5-bromo-uridines showed selective activity against feline herpes virus replication in cell culture due to a specific recognition (activation) by the virus-encoded thymidine kinase.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127735 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2011.05.037 | DOI Listing |
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