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Spontaneous excretion of a pseudomembranous intestinal cast in an infant with an acute diarrhoeal illness: A case report and literature review.
JPGN Rep
November 2024
Department of Paediatric Gastroenterology Hepatology and Nutrition, Royal Hospital for Children and Young People Edinburgh UK.
We present a case of an 8-week-old infant with acute bloody diarrhoea and subsequent passage of an intestinal cast. An extensive immune and infection work-up did not reveal a causative aetiology. Histopathology indicated the cast represented an intestinal pseudomembrane.
View Article and Find Full Text PDFThe evidence for probiotics in the treatment of digestive disorders in the pediatric population.
J Gastroenterol Hepatol
November 2024
Department of Pathology, Tan Tock Seng Hospital, Singapore, Singapore.
Health claims for many probiotic-labeled products are poorly substantiated. This technical review addressed the clinical question: "Do probiotics have a role in the management of the following conditions in childhood?" Evidence supports efficacy for probiotic strains of Saccharomyces boulardii, Lactobacillus reuteri, and Lactobacillus rhamnosus GG for improving outcomes of acute gastroenteritis, of S. boulardii and L.
View Article and Find Full Text PDFDiscovery and Total Synthesis of Anhydrotuberosin as a STING Antagonist for Treating Autoimmune Diseases.
Angew Chem Int Ed Engl
January 2025
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Article Synopsis
- Researchers identified the STING pathway's excessive activation as a cause of autoimmune diseases like SAVI and IBD, making the search for effective STING antagonists crucial.
- They discovered a natural product called anhydrotuberosin (ATS) as a strong STING antagonist through extensive screening but faced challenges with its limited supply.
- A new, efficient synthesis method for ATS was developed, allowing for further studies that revealed its potential in treating inflammation in autoimmune conditions with minimal toxicity.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts.
Immun Inflamm Dis
October 2024
Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy.
Objective And Rationale: Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, manifests with chronic intestinal inflammation and frequent sequential fibrosis. Current pharmacological therapies may show harmful side effects and are not useful for prevention or resolution of fibrosis. Thus, the use of alternative therapies is emerging as a novel useful approach.
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