AI Article Synopsis
- CD147, also known as basigin, is a transmembrane protein found in various tissues, including the brain and heart, and plays roles in immune function and tissue repair.
- It interacts with other proteins that influence processes like lymphocyte activation and cancer progression, while also affecting levels of amyloid-β peptide, which is linked to Alzheimer's disease.
- The review discusses how CD147 may regulate the production and clearance of amyloid-β, highlighting potential mechanisms for managing levels to impact Alzheimer's development.
Article Abstract
CD147, also known as basigin, EMMPRIN, neurothelin, TCSF, M6, HT7, OX47, or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues including the hippocampus, pre-frontal cortex thyroid, heart, early erythroid, amygdala, and placenta. This protein is involved in various cellular and biological functions, such as lymphocyte migration and maturation, tissue repair cancer progression, T and B lymphocyte activation, and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with other proteins such as cyclophilin A (CyPA), Cyclophilin B (CyPB), sterol carrier protein (SCP), caveolin-1 and integrins, and can influence amyloid-β (Aβ) peptide levels, a protein that is central to Alzheimer's disease (AD) pathogenesis. Mechanisms by which CD147 regulate Aβ levels remain unclear, thus in this review we discuss its involvement in Aβ production and clearance and potential mechanisms by which controlling CD147 levels could impact on Aβ accumulation and AD pathogenesis.
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| http://dx.doi.org/10.3233/JAD-2011-110584 | DOI Listing |
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