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An Interesting Case of Vitamin D-Mediated Severe Hypercalcemia in a Patient With Renal Mass.
JCEM Case Rep
January 2025
Department of Medical Oncology, Dr. Jeyasekharan Medical Trust Hospital & Nursing Home, Nagercoil, Tamilnadu 629003, India.
Hypercalcemia of malignancy (HCM) is the most common cause of hypercalcemia in hospitalized patients. The pathogenesis of HCM is often multifactorial. One of the rare causes of HCM is extra-renal production of 1,25-dihydroxyvitamin D (or calcitriol), which is often seen in patients with lymphoproliferative malignancies.
View Article and Find Full Text PDFBreast Adenocarcinoma and Cold Agglutinin Disease: A Paraneoplastic Syndrome.
Cureus
November 2024
Department of Oncology, Medical University of South Carolina, Charleston, USA.
Autoimmune hemolytic anemia is a disorder that is characterized by the destruction of red blood cells through an autoimmune process, such as temperature-dependent antibodies. The two predominant types, cold agglutinin and warm agglutinin disease, typically possess different underlying etiologies. Prompt recognition and workup of autoimmune hemolytic anemia should be prioritized to potentially uncover any underlying primary cause, such as malignancy.
View Article and Find Full Text PDFClinical and Biochemical Profiles of Hospitalized Patients with Hypercalcaemia from a Tertiary Care Centre in North India.
touchREV Endocrinol
October 2024
Department of Endocrinology, Bharti Hospital & BRIDE, Karnal, India.
The profile of hypercalcaemia in hospitalized patients in India seems to be changing. However, studies evaluating the profile of hypercalcaemia in hospitalized settings in India are extremely limited. This prospective study aims to evaluate the clinical and biochemical profile of hospitalized patients with hypercalcaemia from a tertiary care centre in north India.
View Article and Find Full Text PDFThe Constellation of Risk Factors and Paraneoplastic Syndromes in Cholangiocarcinoma: Integrating the Endocrine Panel Amid Tumour-Related Biology (A Narrative Review).
Biology (Basel)
August 2024
Department of Internal Medicine and Gastroenterology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Article Synopsis
- - Cholangiocarcinomas (CCAs) are complex malignant tumors from the biliary epithelium, with increasing global incidence and various risk factors such as chronic liver diseases, lifestyle choices, and genetic factors
- - The review highlights the endocrine features related to CCAs, including associations with conditions like obesity and diabetes, alongside various paraneoplastic syndromes that manifest in patients
- - Humoral hypercalcemia is noted as the most common paraneoplastic syndrome in CCAs, signaling poor prognosis and requiring treatment beyond the typical cancer therapy
Parathyroid Hormone Related Protein Mediated Hypercalcaemia Due to Metastatic Squamous Cell Carcinoma Originating from Pilonidal Disease: A Case Report.
Br J Hosp Med (Lond)
August 2024
Department of Histopathology, Mater Dei Hospital, Birkirkara, Malta.
A 56-year-old male presented with a longstanding, gradually enlarging, painful, skin lesion over the natal cleft. This was initially thought to be a pilonidal abscess but, following multiple surgeries, he was diagnosed with Stage IVb squamous cell carcinoma of the natal cleft skin with bilateral inguinal lymph node metastases and subcutaneous metastatic deposits. Complete surgical cure was not possible.
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