Unlabelled: Essential hypertension is no longer un uncommon disease in children. This study try to determine if carotid intima thickness is increased in children with essential hypertension.
Material And Method: This subjects are compared with control group with normal blood pressure. The study group consists of 78 children with essential hypertension; there were excluded cases with secondary hypertension. These children had carotid intima media thickness, left ventricular mass index and body mass index performed. In control group there were 53 subjects and there were performed the same investigations for them.
Results: Sixtyfour cases (82.05%) from study group had obesity (body mass index > or = 85 percentile). Left ventricular mass index was increased in 40 cases (51.28%). Increased carotid intima media thickness was found in fiftyone subjects (65.38%) in the group of hypertensive children and it range between 0.52 si 0.69 mm. In the control group carotid intima media thickness varies between 0.32 si 0.54 mm. The carotid intima media thickness correlated with sistolic blood pressure (P = 0.00000), with diastolic blood pressure (p = 0.000002), with body mass index (p = 0.00000) and with body mass index(p = 0,000001).
Conclusion: The study could not state if increased carotid intima media thickness is due to hypertension or to obesity, because in children there is a strong association between these two diseases. Anyway, evaluation of this parameter may offer information about early endothelial disfunction.
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Physiol Rep
February 2025
Department of Biomedical Engineering, Toyo University, Saitama, Japan.
The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs.
View Article and Find Full Text PDFObjectives: This study explores the relationship between obesity, endothelial dysfunction, and the critical role of oxidative stress biomarkers in subclinical atherosclerosis.
Design & Methods: The study included 114 adolescents aged 12-17 years from Juiz de Fora, Brazil, divided into 40 individuals with obesity and 74 controls. Physical and biochemical assessments were conducted, including measurements of Brachial Flow-Mediated Dilation (BFMD), Carotid Intima-Media Thickness (IMT), and oxidative biomarkers such as nitrite, nitrate, and 8-isoprostane.
Rev Cardiovasc Med
January 2025
The First School of Clinical Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China.
Background: Given the close relationship between excessive cortisol secretion and obesity, as well as their intimate associations with cardiometabolic sequelae, this study aimed to evaluate whether elevated cortisol levels and obesity are independently and potentially interactively related to hypertension-mediated organ damage (HMOD) in patients with untreated hypertension.
Methods: A total of 936 untreated hypertensive patients were recruited. Body mass index (BMI), 24-hour urinary free cortisol (24 h UFC), and HMOD indicators, including left ventricular hypertrophy (LVH), carotid intima-media thickness (CIMT), and albuminuria, were assessed.
Circulation
January 2025
Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease, Baltimore, MD (Z.Y., E.T., Z.A.D., K.K.J., N.O., T.R., E.B., M.J.B.).
Background: Understanding the association of tobacco product use with subclinical markers is essential in evaluating health effects to inform regulatory policy. This is particularly relevant for noncigarette products (eg, cigars, pipes, and smokeless tobacco), which have been understudied because of their low prevalence in individual cohort studies.
Methods: This cross-sectional study included 98 450 participants from the Cross-Cohort Collaboration-Tobacco data set.
A hospital based cross sectional study involving children aged 2-15 years attending the obesity clinic of a tertiary care hospital from January 2016 to March 2018 was carried out to study carotid intima media thickness (cIMT) and its association with cardiometabolic risk factors in children with overweight and obesity. Secondary objective was to compare children with elevated (EcIMT) and normal cIMT (NcIMT). Out of 223 patients enrolled for the study, 102 (45.
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