Low intensity pulsed ultrasound (LIPUS) was proven to enhance fracture healing effectively. Similar effect of LIPUS on accelerating the osteoporotic fracture healing was therefore hypothesized. The normal and osteoporotic fracture healings under this non-invasive biophysical intervention of LIPUS were compared and investigated. Closed femoral fracture procedures were performed on 120 Sprague-Dawley rats, in which 60 of them were ovariectomized (OVX). The rats were randomly assigned into four groups: sham OVX with treatment (Sham-T), sham OVX control (Sham-C), OVX with treatment (OVX-T) and OXV control (OVX-C). LIPUS treatment was 20 min a day, 5 days a week for durations of 2, 4, or 8 weeks. Results from weekly radiography, histomorphometry, micro-computed tomography and mechanical test showed both the treatment groups were with better healing responses than their control groups. Moreover, between the normal and the osteoporotic treatment groups, a significantly higher (p = 0.015) callus width (week 4), higher ratio of increment in bone volume to tissue volume ratio value (7.4% more), faster response of endochondral ossification and a higher stiffness measurement were observed in the osteoporotic treatment group. These comparable results on healing responses imply that LIPUS can be applied clinically to enhance both normal and osteoporotic fracture healing.
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