This is a case of a 63-year-old Asian female patient who presented to accident and emergency with a febrile illness 3 weeks after her return from the Indian subcontinent. She was given empirical treatment with ciprofloxacin. Blood cultures grew a quinolone-resistant resistant Salmonella paratyphi A so she was re-called, admitted to hospital and treated with intravenous cefotaxime. She did not have known risk factors for invasive salmonellosis. On day 8 she complained of back pain, but since her fever was settling an MRI of the spine was not performed at that point.On day 19 her fever relapsed so the MRI was done and showed images consistent with vertebral osteomyelitis at T7-T8 level. She completed 8 weeks of intravenous antibiotic therapy with good clinical response and normalisation of inflammatory markers, and was discharged on an 8 week course of oral azithromycin. On follow-up after 7 months, her back pain had settled and an MRI showed improvement.
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http://dx.doi.org/10.1136/bcr.07.2008.0400 | DOI Listing |
IDCases
December 2024
Division of Infectious Diseases, Department of Medicine, University of Kansas, Kanas City, KS, USA.
A 55-year-old-male with a chronic left uretero-pelvic junction (UPJ) obstruction managed with intermittent stent exchanges presented with low midline back pain. CT Abdomen/Pelvis revealed spondylodiscitis at L4-L5, further demonstrated on MRI Lumbar spine. Imaging also revealed the left nephro-ureteral stent was mispositioned, with some mild wall thickening of the left ureter.
View Article and Find Full Text PDFSpine (Phila Pa 1976)
December 2024
University of Missouri-Kansas City School of Medicine, 2411 Holmes St, Kansas City, MO 64108.
Study Design: Systematic Review and Network-Meta-analysis.
Purpose: This study aimed to systematically review the literature on management of primary osteomyelitis discitis and perform a network meta-analysis comparing the efficacy of different antibiotic treatment durations.
Background: Primary osteomyelitis discitis is a challenging condition with varying management strategies.
Int J Infect Dis
December 2024
Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Objectives: The aims of this study were 1) to investigate seasonal epidemiological variations of pyogenic spondylodiscitis, including Methicillin-resistant Staphylococcus aureus (MRSA) infection, in Japan, and 2) to evaluate associated inpatient outcomes.
Methods: We performed a retrospective nationwide study using data from the Japanese Diagnosis Procedure Combination (DPC) inpatient database, covering the period from 2010 to 2022. The parameters assessed were seasonal incidence, demographic characteristics, inpatient mortality, complications, and medical costs.
AJNR Am J Neuroradiol
December 2024
From the Department of Radiology (DGM., MVS., GMS., REG., JSR., TJR.) Mayo Clinic, Phoenix, AZ, USA; Department of Radiology (FED.), Mayo Clinic, Rochester, MN, USA. Department of Radiology (EHM.), Mayo Clinic, Jacksonville, FL, USA.
Background And Purpose: Studies show a modest yield for image-guided biopsy of suspected vertebral osteomyelitis-discitis. Many studies evaluate factors to improve diagnostic yield, and few studies assess how biopsy results impact clinical management. We aim to evaluate the impact of biopsy results on clinical management in suspected vertebral osteomyelitis-discitis.
View Article and Find Full Text PDFInfection
December 2024
Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.
Purpose: Patients with vertebral osteomyelitis (VO) and comorbidities, notably chronic kidney disease (CKD), are at risk of early mortality. The aim of this study was to compare characteristics and outcomes of VO patients with an underlying malignancy (ONCO) to VO patients with CKD and VO patients without comorbidities (CONTROL).
Methods: We performed a retrospective analysis of data which was prospectively collected between 2008 and 2020.
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