This case involves a 36 year old non-smoker who worked in a factory producing food flavourings for potato crisps. He developed exertional breathlessness associated with fixed airway obstruction shortly after an uncharacteristically high exposure to the food flavouring chemical diacetyl. Unfortunately, even though he was removed from further exposure to this agent, his symptoms and spirometry did not improve.
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http://dx.doi.org/10.1136/bcr.09.2008.0990 | DOI Listing |
Front Toxicol
May 2023
Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Hannover, Germany.
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference data indicate that the α-diketone diacetyl induces bronchiolitis obliterans in workers involved in the preparation of microwave popcorn. The other three α-diketones induced inflammatory responses in preclinical animal studies, whereas beta and gamma diketones in addition caused neuronal effects.
View Article and Find Full Text PDFNurse Educ
February 2023
Assistant Professor (Drs Wands, Modly, and Coombe), Clinical Track, Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.
Front Public Health
June 2022
Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States.
Lung
August 2021
Pulmonary and Critical Care Service, Brooke Army Medical Center, JBSA Fort Sam Houston, San Antonio, TX, USA.
The case definition of inhalational constrictive bronchiolitis (CB) has changed over the generations. We identify changes in the description of this illness over time associated with different exposures and present the natural history of CB in a case attributed to military burn pit exposure. The initial descriptions of this disease began with nitric acid spills and silage exposures.
View Article and Find Full Text PDFSci Total Environ
June 2021
Department of Public Health, The Brody School of Medicine, East Carolina University, Greenville, NC, USA; Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, Greenville, NC, USA. Electronic address:
Diacetyl (CHO) is a toxicant commonly found in electronic cigarettes (e-Cigs) as a flavoring component and an enhancer of e-juices. Lung injury in current and former workers in popcorn manufacturing suggests a possible association with diacetyl inhalation exposure. Although the number of e-Cig users continues to rise steadily among the teens and adults, the potential risk of pulmonary disease has not been characterized.
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