The results of examining patients aged 10 to 15 years suffering from vegetovascular dystonia (VVD) associated with the tetanic syndrome (TS) are provided. Patients with VVD not associated with the TS, and healthy patients of the comparable age made up the control. Use was made of the electrophysiological techniques (EEG, EMG, REG), vegetological methods (background, reactivity, activity support), neuropsychological (MMPI, Spielberger and Izenk tests), polygraphic and biochemical methods. The authors describe a number of disease characteristics (predominance of the latent forms of the TS, the normal calcemic pattern of tetany, etc). Emphasize the role of nongross lesions of the nonspecific integrating brain systems in the genesis of the given syndrome determined by perinatal injury to the brain.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities.
Genome Med
November 2024
Michael Smith Laboratories, University of British Columbia, Vancouver, Canada.
Background: Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required.
Methods: Here, we computationally map genetic networks of KMT2D, a tumour suppressor gene frequently mutated in several cancer types.
An and efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs.
Mol Ther Methods Clin Dev
December 2024
SwanBio Therapeutics, Inc., Philadelphia, PA, USA.
Adrenomyeloneuropathy is a progressive neurodegenerative disease caused by pathogenic variants in the gene, resulting in very-long-chain fatty acid (VLCFA) accumulation that leads to dying-back axonopathy. Our candidate gene therapy, SBT101 (AAV9-human [h]), aims to ameliorate pathology by delivering functional copies of h to the spinal cord. Transduced cells produce functional ABCD1 protein, thereby repairing the underlying biochemical defect.
View Article and Find Full Text PDFPerfusion Process Intensification for Lentivirus Production Using a Novel Scale-Down Model.
Biotechnol Bioeng
November 2024
Biopharmaceutical Product Development, CSL Innovation GmbH, Marburg, Germany.
Process intensification has become an important strategy to lower production costs and increase manufacturing capacities for biopharmaceutical products. In particular for the production of viral vectors like lentiviruses (LVs), the transition from (fed-)batch to perfusion processes is a key strategy to meet the increasing demands for cell and gene therapy applications. However, perfusion processes are associated with higher medium consumption.
View Article and Find Full Text PDFGenome-wide methylation and transcriptome differential analysis of skeletal muscle in broilers with valgus-varus deformity.
Br Poult Sci
November 2024
College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, China.
1. Valgus-varus deformity (VVD) is a disease that severely affects leg function in broilers and for which there is no effective control method current available. Although DNA methylation has an important impact on most physiological and pathological processes, its involvement in skeletal muscle growth and development in VVD broilers is unknown.
View Article and Find Full Text PDFGenetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.
Nat Genet
September 2024
Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Article Synopsis
- Telomeres are protective caps on chromosomes, and their length is related to aging and diseases, prompting a study on telomere length in over 462,000 UK Biobank participants.
- Researchers created a new metric for measuring telomere length that improved understanding of its genetic control and identified 64 genetic variants and 30 genes linked to telomere length.
- Notably, many of these genes are involved in clonal hematopoiesis, which is linked to certain cancers, indicating a complex relationship between rare genetic variants and telomere length.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!